海南医科大学学报2026，Vol.32Issue(7)：481-487,7.DOI:10.13210/j.cnki.jhmu.20250422.003
一种犬创伤性气管狭窄模型的建立及3D打印支架对气管狭窄的影响
A model of trauma tracheal stenosis in beagle and the effect of 3D printed stents on tracheal stenosis
摘要
Abstract
Objective:To investigate the effects of Argon Plasma Coagulation(APC)on simulated tracheal traumatic stenosis(TTS),we observed the resulting tracheal changes through bronchoscopy and gross anatomical assessment,and further explored the use of 3D printed silicone stent implantation as a novel clinical treatment strategy for TTS.Methods:Nine Beagles were ran-domly divided into three groups,with three Beagles in each group.The control group underwent bronchoscopy to observe the tra-cheal lumen following general anesthesia.In the model group,modeling was performed using APC cauterization after general anes-thesia.The 3D-printed stent treatment group also underwent modeling with APC cauterization after general anesthesia,and 3D-printed silicone stents were implanted on the 21st day.The tracheal lumen was observed via bronchoscopy on days 1,7,14,21,and 28.Pathological features were assessed using the hematoxylin-eosin staining method and Masson staining on day 28.Re-sults:APC cauterization of the trachea allowed for modeling of TTS in Beagles.At day 28,the degree of stenosis was approxi-mately 92%-99%in the model group and 28%-36%in the 3D-printed stent-treated group.Histopathologic features were different between the three groups.Conclusions:APC cauterization of the trachea to establish a model of TTS in beagle dogs is relatively simple,reliable,and inexpensive.3D printed stents can significantly alleviate the degree of stenosis in traumatic airway stenosis.关键词
创伤性气管狭窄/氩离子束凝固术/动物模型/3D打印支架/治疗Key words
Traumatic tracheal stenosis/Argon ion beam coagulation/Animal models/3D printed stents/Treatments分类
医药卫生引用本文复制引用
杨泽华,吴海洪,刘凯,石翠翠,李亚清..一种犬创伤性气管狭窄模型的建立及3D打印支架对气管狭窄的影响[J].海南医科大学学报,2026,32(7):481-487,7.基金项目
This study was supported by the Key Research and Development Project of the Science and Technology Department of Hainan Province(ZDYF2022SHFZ281) 海南省科技厅重点研发项目(ZDYF2022SHFZ281) （ZDYF2022SHFZ281）
