华东理工大学学报（自然科学版）2026，Vol.52Issue(2)：185-192,8.DOI:10.14135/j.cnki.1006-3080.20250715001
基于药物递送系统的木犀草素脂质体纳米颗粒的可控构建
Controlled Fabrication of Luteolin-Loaded Liposomal Nanoparticles for Drug Delivery Systems
宋萌 1岑莲1
作者信息
- 1. 华东理工大学化工学院,上海 200237
- 折叠
摘要
Abstract
A circular microfluidic device was developed using a microfluidic approach combined with numerical simulation and experimental validation to successfully construct and regulate the performance of luteolin-loaded liposomes(Lut Lips).The effects of operational parameters,including total flow rate and flow rate ratio,on the mixing performance of the microfluidic device were systematically investigated,as well as the influence of formulation variables,including mass ratio of phospholipid-to-cholesterol and mass concentration of luteolin,on liposome particle size and luteolin encapsulation efficiency.Under optimized conditions,Lut Lips with a particle size of 220.5 nm and an encapsulation efficiency(EE)of 64.72%were obtained,exhibiting excellent monodispersity with a polydispersity index(PDI)of 0.037.Human immortalized keratinocytes(HaCaT)were used as an in vitro uptake model and co-incubated with fluorescently labeled liposomal nanoparticles(Lips),demonstrating that the delivery system effectively penetrated the cellular membrane barrier and achieved intracellular drug delivery.The findings of this study confirm the feasibility of liposomal nanoparticles as a novel drug delivery system for luteolin and provide new insights and experimental evidence for the design of delivery systems for luteolin and other lipophilic drugs.关键词
脂质体纳米颗粒/微流控/木犀草素/细胞摄取/药物递送Key words
liposomal nanoparticles/microfluidics/luteolin/cellular uptake/drug delivery分类
化学化工引用本文复制引用
宋萌,岑莲..基于药物递送系统的木犀草素脂质体纳米颗粒的可控构建[J].华东理工大学学报（自然科学版）,2026,52(2):185-192,8.
