华东理工大学学报（自然科学版）2026，Vol.52Issue(2)：193-203,11.DOI:10.14135/j.cnki.1006-3080.20250525001
Vamorolone通过调节Th17/Treg细胞平衡改善系统性红斑狼疮小鼠的肾脏损伤
Vamorolone Ameliorates Renal Injury in Mice with Systemic Lupus Erythematosus by Modulating Th17/Treg Cell Balance
肖运平 1杜思铭 1郝爱静 1黎晓雯 1黄思梦 1王蕊1
作者信息
摘要
Abstract
While traditional glucocorticoids are effective in treating systemic lupus erythematosus(SLE),their long-term use is associated with severe side effects.This study aims to explore the therapeutic effects of the novel dissociative steroid Vamorolone on SLE and elucidate its key immunomodulatory mechanisms.We systematically evaluated the efficacy of Vamorolone in two classical SLE animal models,providing critical preclinical evidence for its potential as an alternative to conventional glucocorticoids.In both the spontaneous lupus MRL/lpr and Pristane-induced SLE mice models,Vamorolone significantly improved survival rates,reduced serum anti-dsDNA antibody levels,and effectively ameliorated renal function indicators such as proteinuria and serum creatinine.Renal histopathological analysis revealed that Vamorolone significantly alleviated glomerular cell proliferation,basement membrane thickening,and IgG immune deposition.Mechanistically,Vamorolone exerted its effects by reshaping immune balance:it primarily increased the levels of immunosuppressive Treg cells in the MRL/lpr model,while predominantly reducing the proportion of pro-inflammatory Th17 cells in the Pristane model,achieving an effective reduction in the Th17/Treg ratio.This study confirms the significant efficacy of Vamorolone in treating SLE,demonstrating that by modulating the Th17/Treg cell balance,it effectively mitigates renal damage in SLE mice with differing pathological backgrounds.This suggests Vamorolone holds promise as a new generation of safe and effective SLE therapeutic agent.关键词
系统性红斑狼疮/Vamorolone/类固醇药物/Th17细胞/Treg细胞Key words
systemic lupus erythematosus/Vamorolone/steroid drug/Th17 cell/treg cell分类
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肖运平,杜思铭,郝爱静,黎晓雯,黄思梦,王蕊..Vamorolone通过调节Th17/Treg细胞平衡改善系统性红斑狼疮小鼠的肾脏损伤[J].华东理工大学学报（自然科学版）,2026,52(2):193-203,11.
