郑州大学学报（医学版）2026，Vol.61Issue(2)：1-6,6.DOI:10.13705/j.issn.1671-6825.2025.09.211
心脏纤维化进程中免疫细胞与成纤维细胞互作的研究进展
Research progress of interaction between immune cells and fibroblasts during cardiac fibrosis
摘要
Abstract
Cardiac fibrosis is characterized by pathological deposition of extracellular matrix(ECM),leading to progres-sive deterioration of cardiac structure and function.The interaction between immune cells and cardiac fibroblasts is a pivotal mechanism driving fibrosis.Immune cells such as neutrophils,macrophages and lymphocytes activate fibroblast-to-myofibro-blast transition via cytokine secretion,direct celluar contact and inflammatory micro-environment modulation,while the acti-vated fibroblasts and ECM remodeling reciprocally regulates immune phenotypes,forming a vicious cycle and aggravating the progress of cardiac fibrosis.Targeting the interaction network between immune cells and fibroblasts has showed potential to reverse fibrosis.This article reviewed the interaction mechanism between immune cells and fibroblasts during the progression of cardiac fibrosis,providing insights for the treatment of cardiac fibrosis targeting immune cells and fibroblasts.关键词
免疫细胞/成纤维细胞/心脏纤维化/靶向治疗Key words
immune cells/fibroblasts/cardiac fibrosis/targeted therapy分类
医药卫生引用本文复制引用
贺瑞鹏,郭嘉城,谢诗瑶,张金盈,唐俊楠..心脏纤维化进程中免疫细胞与成纤维细胞互作的研究进展[J].郑州大学学报（医学版）,2026,61(2):1-6,6.基金项目
河南省重点研发专项(241111313300) （241111313300）
国家自然科学基金项目(82222007,82170281,82400336) （82222007,82170281,82400336）
