中医学报2026，Vol.41Issue(5)：915-921,7.DOI:10.16368/j.issn.1674-8999.2026.05.134
基于"分子-证候"双维度探讨不同亚型小细胞肺癌的中医精准辨治思路
Precise TCM Diagnosis and Treatment Approaches for Different Subtypes of Small Cell Lung Cancer in"Molecular-Syndrome"Dual Dimensions
摘要
Abstract
Small cell lung cancer(SCLC)is a highly aggressive neuroendocrine tumor.Currently,the most common subtype classifica-tion of SCLC is mainly based on transcription factors,defined as SCLC-A,SCLC-N,SCLC-P,SCLC-I,and other subtypes.This pa-per systematically constructs,for the first time,the mapping relationship between SCLC molecular subtypes and traditional Chinese med-icine(TCM)syndromes and proposes"molecular-syndrome co-evolution"hypothesis.A precise medication scheme of"syndrome recognition-syndrome differentiation-compound formula"is designed,organically combining SCLC molecular subtyping with TCM syndrome differentiation and treatment.This can,to some extent,overcome the limitations of traditional treatment and provide a new par-adigm for individualized precision therapy.At the same time,it can reveal the biological basis of TCM syndromes at the molecular level(for example,the association of the SCLC-I subtype with the immune microenvironment of"Yin deficiency with internal Heat,defi-ciency of the body's Zheng Qi with lingering Evil Factors"syndrome),breaking through the bottleneck of TCM theory's"abstract-ness".Although this theoretical framework requires further basic research and clinical validation,its integrative thinking is expected to provide certain reference value for tumor treatment.In the future,it is necessary to establish a dynamic correlation model between molec-ular subtypes and TCM syndromes,develop a standardized efficacy evaluation system,and conduct multicenter clinical studies to verify the feasibility of the"molecular-syndrome co-evolution"model based on the dual dimensions of"molecule-syndrome".关键词
小细胞肺癌/分子分型/中医辨证/精准诊疗/分子/证候/辨病/辨型/辨证Key words
small cell lung cancer/molecular subtyping/TCM syndrome differentiation/precision diagnosis and treatment/molecular/syndrome/disease differentiation/type differentiation/syndrome differentiation分类
医药卫生引用本文复制引用
李姝蒙,张甘霖,李慧,成琳,吴静红,马腾,杨国旺..基于"分子-证候"双维度探讨不同亚型小细胞肺癌的中医精准辨治思路[J].中医学报,2026,41(5):915-921,7.基金项目
国家重点研发计划项目(2018YFC1705101) （2018YFC1705101）
