中医学报2026，Vol.41Issue(5)：947-952,6.DOI:10.16368/j.issn.1674-8999.2026.05.138
论低黏附性胃癌的肿瘤微环境与"脾虚瘀毒"病机理论的相关性
Correlation Between Tumor Microenvironment and Pathogenesis of"Spleen Deficiency,Stasis and Toxin"in Poorly Cohesive Gastric Cancer
摘要
Abstract
Poorly cohesive gastric cancer(PCC)has become an important challenge in gastric cancer research due to its unique patho-logical characteristics and complex tumor microenvironment(TME).Spleen deficiency is the fundamental pathogenic mechanism of PCC,persisting throughout the onset and progression of the disease and closely related to the formation of the TME.Based on Spleen de-ficiency,blood stasis and Toxin gradually arise,serving as key pathological factors promoting PCC progression.At the molecular level,there are dynamic associations between spleen deficiency and the immunosuppressive microenvironment,between blood stasis and Toxin with hypoxic microenvironment,between pathogenic effects of Spleen deficiency and inflammatory microenvironment,and between Phlegm generated by Spleen deficiency and acidic microenvironment.Clarifying the homology between the"Spleen deficiency,blood sta-sis and Toxin"of PCC and the tumor microenvironment may provide new insights for the clinical prevention and treatment of poorly co-hesive gastric cancer and regulation of the tumor microenvironment.关键词
低黏附性胃癌/肿瘤微环境/"脾虚瘀毒"/病机理论/免疫抑制微环境/缺氧微环境/炎性微环境/酸生微环境Key words
poorly cohesive gastric cancer/tumor microenvironment/"Spleen deficiency,blood stasis and Toxin"pathogenesis theory/immunosuppressive microenvironment/hypoxic microenvironment/inflammatory microenvironment/acidic microenvironment分类
医药卫生引用本文复制引用
张卉,张昕睿,金漪澜,徐果,邹玺..论低黏附性胃癌的肿瘤微环境与"脾虚瘀毒"病机理论的相关性[J].中医学报,2026,41(5):947-952,6.基金项目
国家自然科学基金面上项目(81973782) （81973782）
江苏省卫生健康委员会2022年度医学科研立项项目(ZD2022070) （ZD2022070）
