中医学报2026，Vol.41Issue(5)：1031-1036,6.DOI:10.16368/j.issn.1674-8999.2026.05.153
基于OPG/RANKL/RANK信号通路探讨中医"血瘀"与膝骨关节炎
"Blood Stasis"and Knee Osteoarthritis Traditional Chinese Medicine Based on OPG/RANKL/RANK Signaling Pathway
摘要
Abstract
The osteoprotegerin(OPG)/receptor activator of NF-κB ligand(RANKL)/receptor activator of NF-κB(RANK)signa-ling pathway is an important pathway regulating bone resorption and bone remodeling,and is closely related to subchondral bone sclero-sis and osteophyte formation in knee osteoarthritis(KOA).In this pathway,OPG competitively binds to RANKL,blocking the interac-tion between RANKL and RANK,inhibiting osteoclast differentiation,proliferation,activation,and maturation,and inducing their apopto-sis,thereby regulating subchondral bone remodeling.Traditional Chinese medicine(TCM)considers blood stasis to be a key pathologi-cal mechanism of KOA,and clinical treatment based on the concept of"stasis"has been effective,but lacks molecular biological evi-dence.Promoting unobstructed microcirculation within bone,reducing high intraosseous pressure,improving blood coagulation status,and enhancing local blood flow are important directions for the prevention and treatment of this disease.Blood-activating and stasis-resol-ving Chinese medicines can protect joint cartilage by improving bone microcirculation disorders.Among them,kidney-tonifying and blood-activating Chinese medicines that regulate the OPG/RANKL/RANK signaling pathway have shown significant therapeutic effects and are worthy of in-depth study.Current research has certain shortcomings:previous studies have mostly focused on inflammatory cy-tokines in relation to cartilage damage while neglecting the important role of subchondral bone in disease development;although the OPG/RANKL/RANK system can explain the pathogenesis of KOA from the perspective of abnormal bone remodeling and provide a mo-lecular biological basis for the traditional Chinese medicine treatment theory of"blood stasis",the specific mechanisms remain unclear.In the future,molecular biology techniques should be utilized to conduct in-depth and systematic studies of this pathway,making it a new target for guiding the prevention and treatment of KOA with traditional Chinese medicine.关键词
膝骨关节炎/OPG/RANKL/RANK 信号通路/软骨下骨/血瘀/中医药/骨重塑Key words
knee osteoarthritis/OPG/RANKL/RANK signaling pathway/subchondral bone/blood stasis/traditional Chinese medicine/bone remodeling分类
医药卫生引用本文复制引用
司元龙,陈志伟,申建军..基于OPG/RANKL/RANK信号通路探讨中医"血瘀"与膝骨关节炎[J].中医学报,2026,41(5):1031-1036,6.基金项目
甘肃省中医药管理局科研项目(GZK-2018-31) （GZK-2018-31）
