华南农业大学学报2026，Vol.47Issue(3)：361-368,8.DOI:10.7671/j.issn.1001-411X.202601011
禽流感病毒感染进程中宿主细胞线粒体自噬通路的应答与调控机制研究进展
Research progress on the response and regulatory mechanisms of host cell mitophagy pathway in the process of avian influenza virus infection
摘要
Abstract
The frequent outbreaks of avian influenza have caused huge economic losses to the poultry industry.Its pathogen,avian influenza virus(AIV),can infect not only birds,but also some subtypes can infect humans and other animals crossing species barriers,which poses a continuous threat to global biosafety.Autophagy,as a highly conserved degradation process that maintains cellular homeostasis,plays a dual role(both antiviral and proviral)in viral infections.Research has shown that AIV can actively intervene in autophagic flux through viral proteins such as NS1,M2 and PB1-F2 to obtain the membrane structures required for self-replication and evade host immune monitoring,especially targeting mitophagy processes.In addition,virus-induced mitochondrial dysfunction not only leads to an outbreak of reactive oxygen species,but in severe cases,it can further cause mitochondrial oxidative membrane rupture and death,known as"Mitoxyperilysis".This article systematically reviewed the signaling network of AIV-activated mitophagy,focusing on the interaction between viral proteins and core autophagy components,and deeply explored the oxidative stress,lipid peroxidation,and"Mitoxyperilysis"effects caused by mitophagy dysfunction,aiming to provide a theoretical basis for the development of new antiviral strategies targeting host mitochondrial homeostasis.关键词
禽流感病毒/细胞自噬/线粒体自噬/氧化应激Key words
Avian influenza virus/Cellular autophagy/Mitophagy/Oxidative stress分类
农业科技引用本文复制引用
任涛,吴耀棠,魏万祺,林秋燕,陈礼斌..禽流感病毒感染进程中宿主细胞线粒体自噬通路的应答与调控机制研究进展[J].华南农业大学学报,2026,47(3):361-368,8.基金项目
广东省林业科技创新项目(2023KJCX028) （2023KJCX028）
双一流学科建设和提升专项(2023B10564003) （2023B10564003）
国家自然科学基金(32372981) （32372981）
