家畜生态学报2026，Vol.47Issue(4)：118-122,128,6.DOI:10.3969/j.issn.1673-1182.2026.04.016
柯里拉京的药理作用及在兽医临床的应用前景
Pharmacological Effects of Corilagin and Its Application Prospects in Veterinary Clinical Practice
摘要
Abstract
Corilagin is a natural gallotannin compound extracted from traditional Chinese herbal medi-cine.In recent years,the pharmacological activity and mechanism of action of corilagin have received wide-spread attention and research.The paper introduces the pharmacological effects and potential application value of corilagin in the veterinary field in terms of its acquisition,anti-inflammatory,antibacterial,antivi-ral,etc.The mechanism mainly involves interfering with the TLR2 signaling pathway to inhibit the activa-tion of NLRP3,inhibiting the NF-κB pathway activated by the TLR4-MyD88 signal,up-regulating heme oxygenase-1 to reduce the cellular ROS level,scavenging free radicals,inhibiting cyclooxygenase 2,IL-6,IL-1β and TNF-α inflammatory factors production,and reducing bacterial lipopolysaccharide-induced py-roptosis.Corilagin has broad application prospects,and its pharmacological effects provide new options and approaches for the prevention and treatment of infectious diseases and inflammatory diseases in animal husbandry production and veterinary clinical settings.关键词
柯里拉京/药理活性/作用机制/兽药应用Key words
Corilagin/pharmacological activity/mechanism of action/veterinary drug application分类
农业科技引用本文复制引用
彭铭昊,潘晓宇,何杰,辛光岩,段纲,项勋,常华..柯里拉京的药理作用及在兽医临床的应用前景[J].家畜生态学报,2026,47(4):118-122,128,6.基金项目
云南省重大科技专项计划项目(202302AA310020) （202302AA310020）
云南省教育厅科学研究基金项目(2024J0499) （2024J0499）
云南省重大科技专项计划项目(202202AE090024) （202202AE090024）
