解放军医学杂志2026，Vol.51Issue(3)：435-442,8.DOI:10.11855/j.issn.0577-7402.1415.2025.0826
小胶质细胞极化及重编程在脑缺血再灌注损伤中的研究进展
Research advances on microglia polarization and reprogramming in cerebral ischemia-reperfusion injury
摘要
Abstract
Microglia(MG)is an important and inherently innate immune cell in brain tissue.It can play the roles of phagocytosis of pathogens,killing of target cells,antigen presentation,immunomodulation,anti-inflammatory repair,and promotion of neuronal survival,etc.Cerebral ischemia-reperfusion injury(CIRI)is a severe cerebrovascular disease caused by vascular blood flow recanalization secondary to ischemic stroke.In the early stage of CIRI,over-activated M1-type MGs lead to injuries such as inflammatory storm and blood-brain barrier disruption,and in the later stage,M2-type polarization plays a crucial role in anti-inflammatory and functional repair of tissues.However,the interventional therapeutic mechanisms associated with MG and its reprogramming in CIRI have not been clarified.The aim of this paper is to review the potential therapeutic strategies of CIRI based on MG phenotypic regulation,i.e.,MG is involved in alleviating CIRI through phagocytosis and anti-inflammatory and repairing effects,and its anti-inflammatory,anti-oxidative stress,and pro-regenerative abilities are significantly enhanced by metabolic reprogramming and polarization to M2 phenotype,which improves the prognosis by removing cellular debris,inhibiting neuroinflammation,and promoting tissue remodeling,and provides a reference for the in-depth research on MG therapy for CIRI.关键词
脑缺血再灌注损伤/巨噬细胞/小胶质细胞/小胶质细胞极化/代谢重编程Key words
cerebral ischemia-reperfusion injury/macrophages/microglia/microglia polarization/metabolic reprogramming分类
医药卫生引用本文复制引用
李雪莲,白文娅,邵建林..小胶质细胞极化及重编程在脑缺血再灌注损伤中的研究进展[J].解放军医学杂志,2026,51(3):435-442,8.基金项目
This work was supported by the National Natural Science Foundation of China(82401716,82460252),and the Science and Technology Program of Department of Science and Technology of Yunnan Province(202201AY070001-037) 国家自然科学基金(82401716,82460252) （82401716,82460252）
云南省科技厅科技计划项目(202201AY070001-037) （202201AY070001-037）
