神经元区室化线粒体生物发生机制的研究进展
Advances in the mechanism of neuronal compartmentalized mitochondrial biogenesis
摘要
Abstract
Neuronal compartmentalized mitochondrial biogenesis is a complex and precise biological process that involves the dynamic generation of mitochondria in different neuronal compartments,such as soma,axons,and synapses.As the"power plants"and metabolic hubs of neurons,mitochondria require their biogenesis to be strictly regulated in a spatiotemporal manner to meet the energy demands and signal transmission needs of neurons in different functional compartments.In recent years,studies have shown that mitochondrial biogenesis is closely related to neuronal survival,neurite plasticity,and the pathogenesis of several neurological diseases.Modulating key signaling pathways governing compartmentalized mitochondrial biogenesis may improve neuronal energy metabolism and function,thereby offering promising intervention strategies for the treatment of neurological diseases.This review summarizes the research progress on mitochondrial biogenesis in soma and axons of neuron,and its role in neurological diseases.关键词
神经元/区室化/线粒体生物发生/过氧化物酶体增殖物激活受体γ共激活因子-1α/哺乳动物雷帕霉素靶蛋白Key words
neuron/compartmentalization/mitochondrial biogenesis/peroxisome proliferator-activated receptor gamma coactivator-1α/mammalian target of rapamycin分类
医药卫生引用本文复制引用
黄佳,杨雨,周胜强,刘芳..神经元区室化线粒体生物发生机制的研究进展[J].解放军医学杂志,2026,51(3):443-452,10.基金项目
This work was supported by the Academic Inheritance and Communication Project of China Academy of Chinese Medical Sciences(CI2022E014XB),the Natural Science Foundation of Hunan Province(2023JJ60458,2023JJ30367),the Scientific Research Project of Hunan Provincial Health Commission(D202319019427),the Scientific Research Project of Hunan Provincial Administration of Traditional Chinese Medicine(C2022011),the Natural Science Foundation Project of Changsha City(kq2208144),and the Postgraduate Innovation Project of Hunan University of Traditional Chinese Medicine(2024CX043) 中国中医科学院学部委员学术传承与传播专项(CI2022E014XB) （CI2022E014XB）
湖南省自然科学基金(2023JJ60458,2023JJ30367) （2023JJ60458,2023JJ30367）
湖南省卫生健康委科研计划项目(D202319019427) （D202319019427）
湖南省中医药科研计划项目(C2022011) （C2022011）
长沙市自然科学基金(kq2208144) （kq2208144）
湖南中医药大学研究生创新课题(2024CX043) （2024CX043）
