解放军医学杂志2026，Vol.51Issue(3)：461-472,12.DOI:10.11855/j.issn.0577-7402.0971.2025.0528
代谢组学在静脉血栓栓塞性疾病中的应用进展
Advances in the application of metabolomics in venous thromboembolic diseases
摘要
Abstract
Venous thromboembolism(VTE)includes deep vein thrombosis(DVT)and pulmonary embolism(PE)with high mortality and increasing morbidity.Early recognition and diagnosis of VTE is of great clinical significance.Metabolomics is a new discipline that performs qualitative and quantitative analysis of all low molecular weight metabolites of an organism or cell during a specific physiological period.In recent years,many studies have used metabolomics analysis to determine metabolites in patients and experimental animal models with VTE,and a series of biomarkers with potential early diagnosis value have been obtained.Moreover,according to the pathway enrichment analysis of differential metabolites,it is concluded that the pathophysiological processes of VTE may be related to the imbalance of nutrient and energy metabolism,cell signaling,carnitine metabolism,purine metabolism,intestinal microbial metabolism,inflammation and oxidative stress,and genetic correlation.In addition,metabolomics also has certain value in risk stratification and prognosis,clinical efficacy evaluation and clinical monitoring of PE.However,further studies are needed to implement metabolomics for clinical application of VTE.This review summarizes the progress of metabolomics research on early diagnosis,pathogenesis,risk stratification,and clinical efficacy evaluation of VTE.关键词
肺栓塞/深静脉血栓形成/静脉血栓栓塞症/代谢组学Key words
pulmonary embolism/deep vein thrombosis/venous thromboembolism/metabolomics分类
医药卫生引用本文复制引用
罗娇,张静,王璐..代谢组学在静脉血栓栓塞性疾病中的应用进展[J].解放军医学杂志,2026,51(3):461-472,12.基金项目
This work was supported by the Key Research and Development Project of Sichuan Provincial Department of Science and Technology(2022YFS0107),and the Youth Innovation Fund of Sichuan Medical Association(S19011) 四川省科技厅重点研发项目(2022YFS0107) （2022YFS0107）
四川省医学会青年创新基金(S19011) （S19011）
