吉林中医药2026，Vol.46Issue(4)：450-454,5.DOI:10.13463/j.cnki.jlzyy.2026.04.012
健脾祛湿法联合GLP-1RA周制剂治疗脾虚湿蕴证2型糖尿病合并肥胖
Efficacy of the therapy for invigorating the spleen and eliminating dampness combined with GLP-1RA weekly preparation in the treatment of T2DM with the syndrome of spleen deficiency and dampness retention coupled with obesity
摘要
Abstract
Objective To explore the efficacy of the therapy for invigorating the spleen and eliminating dampness combined with glucagon like peptide-1 receptor agonist(GLP-1RA)weekly preparation in the treatment of type 2 diabetes(T2DM)with the syndrome of spleen deficiency and dampness retention coupled with obesity.Methods A total of 98 T2DM patients with the syndrome of spleen deficiency and dampness retention combined with obesity were randomly divided into group A and group B,with 49 cases in each group.Group A was treated with GLP-1RA weekly preparation liraglutide,while group B was given the intervention for strengthening the spleen and dispelling dampness on the basis of group A.Both groups received continuous treatment for 2 months.The clinical efficacy after 2 months of treatment,including TCM syndrome scores,physical indicators,insulin resistance status,and indicators related to the insulin receptor substrate-1(IRS-1)/phosphatidylinositol-3(PI3K)/protein kinase B(Akt)signaling pathway before and after 2 months of treatment,as well as adverse reactions during the treatment period were compared between the two groups.Results After 2 months of treatment,the total effective rate,insulin secretion index(HOMA-β),expression levels of serum IRS-1 mRNA,PI3K mRNA,and Akt mRNA of group B were significantly higher,while the TCM syndrome scores,body mass index(BMI),waist circumference,levels of serum fasting insulin(FINS),and insulin resistance index(HOMA-IR)were significantly lower in group B(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The therapy for invigorating the spleen and eliminating dampness combined with GLP-1RA weekly preparation has a better therapeutic effect in the treatment of T2DM with the syndrome of spleen deficiency and dampness retention coupled with obesity,and has good safety.关键词
2型糖尿病/肥胖/脾虚湿蕴证/健脾祛湿法/胰高血糖素样肽-1Key words
type 2 diabetes/obesity/syndrome of spleen deficiency and dampness retention/therapy for invigorating spleen and dispelling dampness/glucagon like peptide-1分类
医药卫生引用本文复制引用
郝永蕾,徐江红,姜波,周颖..健脾祛湿法联合GLP-1RA周制剂治疗脾虚湿蕴证2型糖尿病合并肥胖[J].吉林中医药,2026,46(4):450-454,5.基金项目
河北省中医药管理局科研计划项目(2023226) （2023226）
