检验医学与临床2026，Vol.23Issue(8)：1109-1114,6.DOI:10.3969/j.issn.1672-9455.2026.08.016
宣清和化方联合泼尼松治疗气阴两虚证IgA肾病的疗效及对炎症因子、肾功能的影响
Efficacy of Xuanqing Hehua Fang combined with prednisone in the treatment of IgA nephropathy with Qi-Yin deficiency syndrome and its influence on inflammatory factors and renal function
摘要
Abstract
Objective To investigate the efficacy of Xuanqing Hehua Fang combined with prednisone in treating immunoglobulin A(IgA)nephropathy with Qi-Yin deficiency syndrome and its influence on serum inflammatory factors and renal function.Methods A total of 97 patients with IgA nephropathy presenting with Qi-Yin deficiency syndrome,who were treated in Wuhan Hospital of Traditional Chinese Medicine from October 2022 to August 2024 were enrolled as research subjects,and they were divided into control group(n=48)and combined traditional Chinese and Western medicine group(n=49)by random number table.The control group received oral prednisone on the basis of standard treatment,while the combined traditional Chi-nese and Western medicine group received Xuanqing Huahe Fang on the basis of the control group.The tradi-tional Chinese medcine(TCM)efficacy,TCM syndrome scores,renal function indicators[24 hUrine protein quantification(UTP),serum creatinine(Scr),blood urea nitrogen(BUN)]levels,serum inflammatory factors[vascular cell adhesion molecule(VCAM)-1,monocyte chemotactic protein(MCP)-1]levels,as well as the in-cidence of adverse drug reaction(ADR)in the two groups were compared.Results The TCM efficacy in the combined traditional Chinese and Western medicine group was 93.88%,which was obviously higher than 77.08%in the control group(P<0.05).After 6 months of treatment,the TCM syndrome scores,24 h UTP,as well as Scr,BUN,VCAM-1,MCP-1 levels in both groups were lower than those before treatment,and which in the combined traditional Chinese and Western medicine group were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of ADR between the combined traditional Chinese and Western medicine group and the control group(14.29%vs.10.42%)had no statisti-cally significant difference(P>0.05).Conclusion Xuanqing Hehua Fang combined with prednisone has a better efficacy in patients with IgA nephropathy presenting with Qi-Yin syndrome,and it can effectively downregulate the serum VCAM-1 and MCP-1 levels,obviously improve renal function and alleviate related symptoms,with high safety.关键词
宣清和化方/泼尼松/免疫球蛋白A肾病/肾功能/血管细胞黏附分子-1Key words
Xuanqing Hehua Fang/prednisone/immunoglobulin A nephropathy/renal function/vascular cell adhesion molecule-1分类
医药卫生引用本文复制引用
郑帆,陈小娟,刘涛,宋琼..宣清和化方联合泼尼松治疗气阴两虚证IgA肾病的疗效及对炎症因子、肾功能的影响[J].检验医学与临床,2026,23(8):1109-1114,6.基金项目
湖北省武汉市中医药科研项目(WZ22C57). （WZ22C57）
