检验医学与临床2026，Vol.23Issue(8)：1137-1145,9.DOI:10.3969/j.issn.1672-9455.2026.08.020
子宫腺肌病相关不孕症的病理机制与临床诊疗进展
Pathogenetic mechanisms and advances in clinical management of adenomyosis-associated infertility
摘要
Abstract
Adenomyosis(AM)is a common benign disease among women of reproductive age and a signif-icant cause of secondary infertility.Traditional treatments often come at the expense of fertility,making it dif-ficult to meet patients'reproductive needs.This review summarizes recent research advances in AM-associated infertility from both pathological mechanisms and clinical diagnosis and treatment perspectives.Regarding pathological mechanisms,key aspects such as abnormal uterine structure and contractile function,impaired en-dometrial receptivity,chronic inflammation and immune microenvironment dysregulation,fibrosis and tissue remodeling,and hormonal metabolic disorders are highlighted.In terms of clinical diagnosis and treatment,the application of imaging diagnostic techniques,medication and surgical strategies aimed at improving fertility outcomes,advances in minimally invasive techniques like thermal ablation,and protocol optimization in assis-ted reproductive technology ART are outlined.Currently,the pathological mechanisms of AM-associated in-fertility remain unclear,diagnosis is often subjective and experience-dependent,and treatment strategies lack high-level evidence-based support.Future research should focus on establishing a precise classification system integrating imaging and molecular biomarkers,conducting high-quality clinical studies,and further exploring the mechanisms and ef-ficacy of integrated traditional Chinese and Western medicine in improving fertility outcomes.关键词
子宫腺肌病/不孕/妊娠/病理机制/临床诊疗/进展Key words
adenomyosis/infertility/pregnancy/pathogenesis/clinical diagnosis/advance分类
医药卫生引用本文复制引用
郑瑞,艾雯霞,王甜慧,程英龙,刘丽..子宫腺肌病相关不孕症的病理机制与临床诊疗进展[J].检验医学与临床,2026,23(8):1137-1145,9.基金项目
黑龙江省省属本科高校中央支持地方高校改革发展资金项目(2021ZYGLG001). （2021ZYGLG001）
