检验医学与临床2026，Vol.23Issue(8)：1146-1152,7.DOI:10.3969/j.issn.1672-9455.2026.08.021
非编码RNA在造血干细胞移植后GVHD中的多维调控与临床转化
Multidimensional regulation and clinical translation of non-coding RNAs in GVHD after hematopoietic stem cell transplantation
摘要
Abstract
Allogeneic hematopoietic stem cell transplantation is a key treatment for hematologic diseases,but graft-versus-host disease(GVHD)significantly impairs patient quality of life due to nonspecific symp-toms,lack of standardized diagnostic tools,and treatment resistance.This review systematically summarizes the regulatory mechanisms and translational potential of non-coding RNAs in GVHD.(1)Mechanistic in-sights:non-coding RNAs(including miRNAs,lncRNAs,circRNAs)drive GVHD progression by modulating immune cell activation(e.g.,T/B cell differentiation,macrophage polarization),cytokine storms(e.g.,inter-leukin-6,interferon-γ)and tissue fibrosis(e.g.,transforming growth factor-β/Smad signal pathway).(2)Clinical translation:non-coding RNAs serve as biomarkers(e.g.,miR-155,lncRNA NEAT1)for early diagno-sis;non-coding RNA-based interventions(e.g.,antagomirs targeting miRNAs,exosome-mediated delivery of therapeutic RNA)show therapeutic promise.(3)Current challenges:GVHD diagnosis remains subjective;first-line steroid treatments have high resistance rates;second-line therapies are limited;non-coding RNA re-search faces issues including lack of standardized detection,insufficient targeted delivery technologies,limited in vivo functional models and unclear long-term safety.Key future directions include:(1)large-scale validation of non-coding RNA diagnostic value;(2)development of organ-specific delivery systems(e.g.,liver-targeted nanoparticles);(3)integration of artificial intelligence and multi-omics to establish a comprehensive"mecha-nism-technology-clinical"research framework to advance precise GVHD diagnosis and treatment.关键词
非编码RNA/造血干细胞移植/移植物抗宿主病/生物标志物/精准诊疗Key words
non-coding RNA/hematopoietic stem cell transplantation/graft-versus-host disease/bi-omarker/precision medicine分类
医药卫生引用本文复制引用
冯一梅,古育玲,夏琳,杨世杰,张曦..非编码RNA在造血干细胞移植后GVHD中的多维调控与临床转化[J].检验医学与临床,2026,23(8):1146-1152,7.基金项目
重庆市自然基金项目(cstc2019jcyjmsxmX0273,2025MSXM008) （cstc2019jcyjmsxmX0273,2025MSXM008）
重庆市科技创新与应用开发项目(CSTB2023TIA-STX0008) （CSTB2023TIA-STX0008）
陆军军医大学第二附属医院临床研究专项(2024F026). （2024F026）
