口腔颌面外科杂志2026，Vol.36Issue(2)：139-142,4.DOI:10.12439/kqhm.1005-4979.2026.02.009
炎症微环境中破骨细胞分化及其功能特点的研究进展
Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment
摘要
Abstract
Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption.Inflammation serves as a significant inducer of pathological bone resorption.Studies have shown that osteoclasts differentiated in the inflammatory microenvironment originate from specific marked osteoclast precursors and also exhibit enhanced bone-resorbing capacity compared with those under physiological conditions.Moreover,these inflammation-derived osteoclasts further regulate bone destruction processes through crosstalk with stromal and immune cells.Therefore,osteoclasts in the inflammatory microenvironment are crucial for understanding the pathogenesis of inflammatory bone loss and developing targeted therapeutic strategies.This article reviews the differentiation mechanisms and functional properties of osteoclasts in the inflammatory microenvironment.关键词
炎症/破骨细胞/骨吸收Key words
inflammation/osteoclasts/bone resorption分类
医药卫生引用本文复制引用
王琎,王雅冰,苏俭生..炎症微环境中破骨细胞分化及其功能特点的研究进展[J].口腔颌面外科杂志,2026,36(2):139-142,4.基金项目
国家自然科学基金(82201077) （82201077）
