肝豆状核变性的中医证候学与辨证治疗
Traditional Chinese medicine syndrome and syndrome differentiation-based treatment of Wilson disease
摘要
Abstract
Wilson disease(WD)is an autosomal recessive disorder of copper metabolism,and decoppering therapy and symptomatic treatment are the main Western medicine therapies for WD.This article systematically reviews the understanding of the etiology and pathogenesis of WD in traditional Chinese medicine(TCM)and points out that abnormal natural endowment is the core etiology and pathogenesis of WD,with internal accumulation of copper toxicity as the manifestation,liver/spleen/kidney dysfunction as the root cause,and intermingled"toxin,stasis,phlegm,and deficiency"as the key pathogenesis.Literature research and clinical observation are conducted to summarize the common TCM syndromes of WD,including stagnation of liver Qi,internal retention of damp-heat,phlegm-stasis-heat accumulation syndrome,liver-kidney Yin deficiency syndrome,spleen-kidney Yang deficiency,and syndrome of deficiency damage and phlegm stasis.This article proposes the corresponding therapies and representative prescriptions for each syndrome and discusses the advantages of treatment by stage and integrated traditional Chinese and Western medicine therapy.This article aims to provide a systematic reference for the syndrome differentiation-based treatment of WD in clinical practice of TCM,thereby giving full play to the advantages of TCM in the treatment of this disease.关键词
肝豆状核变性/证候/辨证论治/中医治疗学Key words
Hepatolenticular Degeneration/Symptom Complex/Treatment Based on Syndrome Differentiation/Therapeutics(TCM)引用本文复制引用
郝文杰,杨文明,程婷,江海林,汪瀚,汪美霞..肝豆状核变性的中医证候学与辨证治疗[J].临床肝胆病杂志,2026,42(3):522-528,7.基金项目
国家自然科学基金(U22A20366,82505546) （U22A20366,82505546）
安徽省自然科学基金(2408085QH283) （2408085QH283）
安徽省高等学校科研项目(2024AH051003) （2024AH051003）
安徽省中医药科技攻关专项(202303a07020004) （202303a07020004）
安徽中医药大学临床科研项目(2024YFYLCZX17) （2024YFYLCZX17）
安徽省教育厅科学研究项目(2025AHGXZK40547) （2025AHGXZK40547）
安徽省临床医学研究转化专项(202204295107020066) National Natural Science Foundation of China(U22A20366,82505546) （202204295107020066）
Anhui Natural Science Foundation(2408085QH283) （2408085QH283）
Anhui Higher Education Institutions Scientific Research Project(2024AH051003) （2024AH051003）
Anhui Provincial Special Project for Scientific and Technological Innovation in Traditional Chinese Medicine(202303a07020004) （202303a07020004）
Clinical Research Project of Anhui University of Chinese Medicine(2024YFYLCZX17):Scientific Research Project of the Education Department of Anhui Province(2025AHGXZK40547) （2024YFYLCZX17）
Special Project for Clinical Medical Research Transformation of Anhui Province(202204295107020066) （202204295107020066）
