临床肝胆病杂志2026，Vol.42Issue(3)：718-725,8.DOI:10.12449/JCH260330
基于肠道菌群-胆汁酸轴探讨肝硬化的发病新机制及干预策略
Novel pathogenesis and intervention strategies for liver cirrhosis based on the gut microbiota-bile acid axis
摘要
Abstract
Liver cirrhosis is the final stage of the progression of various chronic liver diseases,often accompanied by serious complications and high mortality rates.Recent studies have shown that the interaction between gut microbiota and bile acid metabolism(the gut microbiota-bile acid axis)is closely associated with liver cirrhosis.This article systematically reviews the mechanism of action of the gut microbiota-bile acid axis in the progression of liver cirrhosis,elaborates on the pathological features of liver cirrhosis and its harm to the body,and summarizes the association of the gut microbiota-bile acid axis with the development and progression of liver cirrhosis.It also analyzes the key regulatory role of this axis in the progression of liver cirrhosis and explores its potential application value as a therapeutic target for liver cirrhosis,in order to provide a theoretical basis for exploring more effective clinical intervention methods.关键词
肝硬化/胃肠道微生物组/胆汁酸类Key words
Liver Cirrhosis/Gastrointestinal Microbiome/Bile Acid引用本文复制引用
刘宁宁,崔文婷,慕淑丽,马秀珍,麦平..基于肠道菌群-胆汁酸轴探讨肝硬化的发病新机制及干预策略[J].临床肝胆病杂志,2026,42(3):718-725,8.基金项目
甘肃省自然科学基金(21JR1RA014) Natural Science Foundation of Gansu Province(21JR1RA014) （21JR1RA014）
