临床口腔医学杂志2026，Vol.42Issue(4)：199-202,4.DOI:10.3969/j.issn.1003-1634.2026.04.003
用于口腔微创治疗的可注射抗菌黏附复合水凝胶的制备及研究
Fabrication and study of an injectable antibacterial adhesive composite hydrogel for oral minimally invasive therapy
周耕宇 1胡靖宇 1马净植1
作者信息
- 1. 华中科技大学同济医学院附属同济医院口腔医学中心 湖北 武汉 430030||华中科技大学同济医学院口腔医学院 湖北 武汉 430030
- 折叠
摘要
Abstract
Objective:To develop a multifunctional injectable hydrogel for oral minimally invasive therapy and evalu-ate its properties.Methods:A polydopamine-modified cellulose nanocrystal/dopamine-drafted hyaluronic acid(PCNC/HA-DA)hydrogel was constructed.Its shear-thinning and self-healing properties were assessed via rheological tests,biocompati-bility with human periodontal ligament cells was examined using CCK-8 assay and live/dead staining,antibacterial and anti-biofilm activities against Streptococcus mutans and Enterococcus faecalis were evaluated by plate counting and crystal violet staining.Results:The hydrogel exhibited significant shear-thinning and rapid self-healing capabilities,allowing smooth injec-tion.Cell experiments confirmed favorable biocompatibility.It showed significant inhibitory effects against both pathogens and effectively suppressed biofilm formation.Conclusion:The PCNC/HA-DA hydrogel integrates injectability,wet-adhesion,anti-bacterial activity,and favorable cytocompatibility,demonstrating potential for oral minimally invasive applications.关键词
可注射水凝胶/抗菌/生物相容性/聚多巴胺/口腔微创治疗Key words
Injectable hydrogel/Antibacterial/Biocompatibility/Polydopamine/Oral minimally invasive therapy分类
医药卫生引用本文复制引用
周耕宇,胡靖宇,马净植..用于口腔微创治疗的可注射抗菌黏附复合水凝胶的制备及研究[J].临床口腔医学杂志,2026,42(4):199-202,4.
