临床神经外科杂志2026，Vol.23Issue(2)：121-125,132,6.DOI:10.3969/j.issn.1672-7770.2026.02.001
1990-2021年中国高收缩压与高LDL胆固醇归因的缺血性脑卒中疾病负担趋势分析
Trend analysis on disease burden of ischemic stroke attribute to high systolic blood pressure and high LDL Cholesterol in China from 1990 to 2021
摘要
Abstract
Objective Based on the data from the 2021 Global Burden of Disease Study(GBD 2021),to explore the impact of different risk factors on deaths and disability-adjusted life years(DALYs)of ischemic stroke(IS)in China.Methods Age-period-cohort(APC)model was used to quantitative evaluation and analyze the trend of deaths and burden of IS attributable to high systolic blood pressure(SBP)and high low-density lipoprotein cholesterol(LDL-C).Results From 1990 to 2021,IS deaths attributed to high SBP continued to increase,with a relatively large proportion of men under 40 and over 80 years old.Although the burden related to high LDL-C decreased overall,it still showed a U-shaped risk distribution,especially in young and elderly men.Conclusions The effects of high SBP and high LDL-C on IS are different in age and gender.In the future,targeted and precise intervention on the impact of high-risk factors in specific age groups on IS is needed to reduce the risk of death from IS and improve the health of the population.关键词
缺血性脑卒中/高收缩压/高LDL-C/APC模型Key words
ischemic stroke/high systolic blood pressure/high LDL-C/APC model分类
医药卫生引用本文复制引用
桑天乙,赵文轩,鲁晓杰..1990-2021年中国高收缩压与高LDL胆固醇归因的缺血性脑卒中疾病负担趋势分析[J].临床神经外科杂志,2026,23(2):121-125,132,6.基金项目
江苏省"十四五"医学重点学科基金项目(ZDXK202227) （ZDXK202227）
