临床神经外科杂志2026，Vol.23Issue(2)：165-170,176,7.DOI:10.3969/j.issn.1672-7770.2026.02.008
MRI参数Ktrans、Kep值与血清miR-487a-3p、miR-490-3p对脑胶质瘤分级的诊断价值
Diagnostic value of MRI parameters Ktrans value and Kep value,and serum miR-487a-3p and miR-490-3p for glioma grading in glioma patients
摘要
Abstract
Objective To discuss the diagnostic value of magnetic resonance imaging(MRI)parameters volume transport constant(Ktrans)and rate constant(Kep),and serum microRNA(miR)-487a-3p and miR-490-3p for glioma grading.Methods From January 2023 to January 2025,80 patients with glioma treated at Luohe Central Hospital were considered as subjects.Complying with the extent of malignancy in clinical pathology,the patients were grouped into a low-grade group of 37 cases(grades Ⅰ-Ⅱ)and a high-grade group of 43 cases(grades Ⅲ-Ⅳ).All patients were subjected to dynamic contrast-enhanced MRI scans to obtain Ktrans and Kepvalues.The qRT-PCR method was performed to detect serum miR-487a-3p and miR-490-3p.Pearson's method for analyzing correlations.Receiver operating characteristic(ROC)curve was used to explore the diagnostic value of MRI parameters Ktrans and Kep values,and serum miR-487a-3p and miR-490-3p in glioma grading.Internal validation of joint diagnostic models using bootstrap methodology.Results The high-grade group had clearly higher Ktrans and Kep values than the low-grade group,and clearly lower serum miR-487a-3p and miR-490-3p than the low-grade group(P<0.05).Serum miR-487a-3p and miR-490-3p were clearly negatively correlated with Ktrans value(r=-0.370,-0.486)and Kep value(r=-0.319,-0.463),respectively(P<0.05).The are under curve(AUC)of Ktrans value,Kep value,miR-487a-3p,and miR-490-3p in the diagnosis of glioma grading was 0.829,0.844,0.841,and 0.839,respectively.The AUC of the joint diagnosis of the four was 0.960,and the joint of the four was better than their individual diagnosis(Zjoint-Ktrans value=3.175,Zjoint-Kep value=2.840,Zjoint-miR-487a-3p=2.734,Zjoint-miR-490-3p=2.491,P<0.05).The internal validation results showed good agreement between the calibration curve and the ideal curve with the Hosmer-Lemeshow test χ2=10.053,P=0.261.Conclusions The joint of MRI parameters Ktrans and Kep values with serum miR-487a-3p and miR-490-3p can significantly enhance the diagnostic efficacy in grading brain gliomas.关键词
脑胶质瘤/肿瘤分级/磁共振成像参数/Ktrans/Kep/miR-487a-3p/miR-490-3pKey words
glioma/tumor grading/magnetic resonance imaging parameter/Ktrans/Kep/miR-487a-3p/miR-490-3p分类
医药卫生引用本文复制引用
陈征,王冲,翟静静,苏刚..MRI参数Ktrans、Kep值与血清miR-487a-3p、miR-490-3p对脑胶质瘤分级的诊断价值[J].临床神经外科杂志,2026,23(2):165-170,176,7.基金项目
河南省医学科技攻关计划项目(LHGJ20191423) （LHGJ20191423）
