临床神经外科杂志2026，Vol.23Issue(2)：171-176,6.DOI:10.3969/j.issn.1672-7770.2026.02.009
血清SOCS3、CCL20对脑胶质瘤患者放疗敏感性的预测价值
Predictive value of serum SOCS3 and CCL20 for radiotherapy sensitivity in patients with glioma
摘要
Abstract
Objective To explore the relationship and predictive value of serum suppressor of cytokine signaling 3(SOCS3)and C-C chemokine ligand 20(CCL20)levels with radiotherapy sensitivity in patients with glioma.Methods From January 2023 to March 2025,122 patients with glioma grades Ⅲ-Ⅳ admitted to Cangzhou People's Hospital were enrolled as the study subjects.Enzyme linked immunosorbent assay(ELISA)was used to detect serum SOCS3 and CCL20 levels.Logistic regression was used to explore the influencing factors.Receiver operating characteristic(ROC)curves were plotted to explore the predictive value.Bootstrap method was employed for internal validation of the calibration of the joint prediction model.Results Among 122 patients with glioma,98 were radiotherapy sensitive,and 24 were radiotherapy insensitivity,with a radiotherapy insensitivity rate of 19.67%.The radiotherapy insensitivity group had higher proportion of tumor pathological grades IV and levels of serum CCL20 before and after treatment than the radiotherapy high sensitive group,while the radiotherapy insensitivity group had lower levels of serum SOCS3 before and after treatment than the radiotherapy high sensitive group(P<0.05).Pre-treatment SOCS3 was an independent protective factor for radiotherapy insensitivity in glioma patients,while pre-treatment CCL20 was an independent risk factor for radiotherapy insensitivity in glioma patients(P<0.05).The area under curve values of predicting radiotherapy insensitivity in glioma patients based on serum SOCS3 and CCL20 levels alone and their combination before treatment were 0.839,0.833,and 0.943,respectively.The calibration curve results showed that the actual probability was basically consistent with the predicted probability,indicating that the joint prediction model had a high calibration degree.Conclusions Low level of serum SOCS3 and high level of CCL20 may be associated with the occurrence of radiotherapy insensitivity in gliomas.The combination of the two can effectively predict the radiotherapy insensitivity in patients with glioma.关键词
脑胶质瘤/放疗敏感性/细胞因子信号转导抑制因子3/趋化因子配体20/预测价值Key words
glioma/radiotherapy sensitivity/suppressor of cytokine signaling 3/C-C chemokine ligand 20/prediction value分类
医药卫生引用本文复制引用
刘姗姗,李明航,杨健,陈冬艳,刘颖,许新明..血清SOCS3、CCL20对脑胶质瘤患者放疗敏感性的预测价值[J].临床神经外科杂志,2026,23(2):171-176,6.基金项目
2026年河北省医研企联合创新专项课题计划(LH20250061) （LH20250061）
