临床误诊误治2026，Vol.39Issue(8)：50-54,5.DOI:10.3969/j.issn.1002-3429.2026.08.009
膝骨关节炎患者血清软骨寡聚基质蛋白表达水平及临床意义
Expression level and clinical significance of serum cartilage oligomeric matrix protein in patients with knee osteoarthritis
摘要
Abstract
Objective To investigate the expression of serum cartilage oligomeric matrix protein(COMP)in patients with knee osteoarthritis(KOA)and its clinical significance.Methods One hundred KOA patients admitted from May 2020 to May 2022 were selected as the observation group,and 100 healthy individuals undergoing physical examinations during the same period were selected as the control group.The gender,age,and body mass index(BMI)of the observation group and the control group were collected.The expression level of serum COMP in the two groups was detected by enzyme-linked immunosorbent assay(ELISA),and the severity of KOA in the patients was graded using the Kellgren-Lawrence(K/L)scale.The expression level of serum COMP was compared between the observation group and the control group,and the correlation of the expression level of serum COMP in KOA patients with baseline data and the K/L grade was analyzed using Pearson and Spearman correlation analyses.Results There was no significant difference in age,gender,and BMI between the observation group and the control group(P＞0.05).The expression level of serum COMP in the observation group was higher than that in the control group(P＜0.0I).The number of KOA patients,age,and BMI in the serum COMP high-expression group were all higher than those in the low-expression group(P＜0.0 1);there was no significant difference in gender between the COMP high-expression group and the low-expression group(P＞0.05).Pearson and Spearman correlation analyses showed that the expression level of serum COMP in the observation group was significantly and positively correlated with BMI and K/L grade(r=0.55,0.62,P＜0.001),and there was no significant correlation with gender and age(r=0.01,0.09,P=0.912,0.359).Univariate logistic regression analysis found that when the expression level of serum COMP changed from low to high,the risk of severe K/L grade increased by 5.22 times.Multivariate logistic regression analysis found that after adjusting for gender,age,and BMI,when the expression level of serum COMP changed from low to high,the risk of severe K/L grade increased by 5.98 times.Conclusion The expression level of COMP in the serum of KOA patients is generally elevated.This expression level can reflect the severity of the disease and can provide a scientific basis for clinical diagnosis and the assessment of treatment efficacy.关键词
膝骨关节炎/软骨寡聚基质蛋白/K/L分级/相关性/风险评估Key words
knee osteoarthritis/cartilage oligomeric matrix protein/K/L grade/correlation/risk assessment引用本文复制引用
张文佳,王汉伟,程坤,郭旭,高磊,周万淼,刘红杰..膝骨关节炎患者血清软骨寡聚基质蛋白表达水平及临床意义[J].临床误诊误治,2026,39(8):50-54,5.基金项目
河北省中医药管理局科研计划项目(2022530) （2022530）
张家口市重点研发计划项目(2221223D) （2221223D）
