西南医科大学学报2026，Vol.49Issue(3)：350-355,6.DOI:10.3969/j.issn.2096-3351.2026.03.014
血清NKG2D和YKL-40表达与NSCLC患者免疫功能的相关性及对其复发的预测价值
Association of Serum NKG2D and YKL-40 Expression with Immune Function and Their Predictive Value for Recurrence in Patients with NSCLC
摘要
Abstract
Objective This study aimed to analyze the relationship between serum natural killer cell activating receptor 2D(NKG2D),chitinase protein-40(YKL-40)expression and immune function in patients with non-small cell lung cancer(NSCLC),and to predict the value of recurrence.Methods A retrospective study was conducted to select 162 patients with NSCLC admitted to the hospital from November 2022 to November 2023 as the study subjects.After 1 year of follow-up after discharge,162 patients were divided into 44 cases(27.16%)in the recurrence group and 118 cases(72.84%)in the non-recurrence group.The general data,serum NKG2 D and YKL-40 levels were compared between the two groups.The correlation between serum NKG2D,YKL-40,and immune function was analyzed by bivariate correlation Pearson.Logistic regression was used to test the effect of various factors on the recurrence of NSCLC patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum NKG2 D and YKL-40 for recurrence in patients with NSCLC.R4.1.0 statistical software was used to draw the decision curve of serum NKG2D and YKL-40 levels to predict the recurrence of NSCLC patients with high risk threshold as abscissa and net return rate as ordi-nate.Results NKG2D exhibited a negative correlation with CD8+(r<0,P<0.05),but a positive correlation with both CD4+/CD8+and NK(r>0,P<0.05).YKL-40 exhibited a positive correlation with CD8+(r>0,P<0.05),but a negative correlation with both CD4+/CD8+and NK(r<0,P<0.05).ROC curve showed that the AUC of serum NKG2 D,YKL-40 alone and combined in predicting the recurrence of NSCLC patients were 0.753,0.737,and 0.848.The decision curve was drawn.The results showed that in the range of 0.070～0.650,0.670～0.733,and 0.767～0.855,the net rate of return of serum NKG2D and YKL-40 combined to predict the recur-rence of NSCLC patients was better than that of single net rate of return.Conclusion The expression of serum NKG2D and YKL-40 in patients with NSCLC has a good correlation with immune function,which is an influencing factor for the recurrence of NSCLC patients.The combined detection of the two indicators has a high predictive value for the recurrence of NSCLC patients,which can guide the development of clinical treatment strategies to a certain extent.关键词
非小细胞肺癌/自然杀伤细胞活化受体2D/甲壳质酶蛋白-40/免疫功能/复发Key words
Non-small cell lung cancer/NKG2D/YKL-40/Immune function/Recurrence分类
医药卫生引用本文复制引用
肖中岳,乔滨,刘志伟..血清NKG2D和YKL-40表达与NSCLC患者免疫功能的相关性及对其复发的预测价值[J].西南医科大学学报,2026,49(3):350-355,6.基金项目
河南省科技攻关计划项目(252102310095) （252102310095）
