国际眼科杂志2026，Vol.26Issue(5)：785-791,7.DOI:10.3980/j.issn.1672-5123.2026.5.10
ANGPTL4在糖尿病视网膜病变中的作用机制及治疗靶点研究进展
Mechanism and therapeutic targets of angiopoietin-like protein 4 in diabetic retinopathy
摘要
Abstract
·Diabetic retinopathy(DR)remains the leading cause of vision loss in patients with diabetes.Current anti-vascular endothelial growth factor(VEGF)therapies are limited by inadequate response in some patients and the necessity for repeated intravitreal injections,underscoring the urgent need for novel therapeutic targets.Angiopoietin-like protein 4(ANGPTL4),a multifunctional secreted protein,has emerged as a critical regulator in the pathogenesis and progression of DR,positioning it as a promising interventional target.This review systematically elaborates the biological characteristics of ANGPTL4,with a focus on its expression dynamics,molecular mechanisms,and regulatory networks rolesin the development of DR.Furthermore,the prospects of ANGPTL4-targeted therapeutic strategies are discussed,aiming to offer new insights and directions for understanding DR pathogenesis,advancing multi-target drug development,and improving clinical management.关键词
血管生成素样蛋白4(ANGPTL4)/糖尿病视网膜病变/分子机制/治疗靶点Key words
angiopoietin-like protein 4(ANGPTL4)/diabetic retinopathy/molecular mechanisms/therapeutic targeting引用本文复制引用
冯靖嵘,李艳,任小草,李纪新,马钰,张文芳,杨义..ANGPTL4在糖尿病视网膜病变中的作用机制及治疗靶点研究进展[J].国际眼科杂志,2026,26(5):785-791,7.基金项目
国家自然科学基金项目(No.82560206) （No.82560206）
朗视界·沐光明中青年眼科科研项目(No.BCF-KH-YK-20240906-02) National Natural Science Foundation of China(No.82560206) （No.BCF-KH-YK-20240906-02）
Langshijie·Muguangming Middle-aged and Young Ophthalmology Research Project(No.BCF-KH-YK-20240906-02) （No.BCF-KH-YK-20240906-02）
