国际眼科杂志2026，Vol.26Issue(5)：823-830,8.DOI:10.3980/j.issn.1672-5123.2026.5.16
葡萄膜黑色素瘤的治疗新进展
Novel therapeutic advances for uveal melanoma
摘要
Abstract
·Uveal melanoma(UM)is the most common primary intraocular malignancy in adults,characterized by high invasiveness and unique metastatic biological features.Although local treatments(such as proton beam therapy and brachytherapy)can effectively control the primary lesion,approximately 50％of patients eventually develop distant metastasis,with the liver being the primary target organ(occurring in 90％of cases).This highlights a paradigm shift in treatment focus from mere local control to systemic prevention and management.For metastatic UM(mUM),current treatment strategies encompass biomarker-guided molecular targeted therapy,immunotherapy(including Tebentafusp,vaccines,and oncolytic virus therapy),and liver-directed therapy.Focusing on the synergy between local and systemic prevention and control,this article systematically elaborates on the precision local treatment for primary UM,the decision-making pathway for systemic treatment of metastatic UM based on molecular subtyping,the integration of local and systemic therapies for liver metastases,and the translational value of nanomedicine in addressing therapeutic bottlenecks.It provides insights for optimizing clinical management of mUM and developing novel therapeutic strategies.关键词
葡萄膜黑色素瘤/转移性葡萄膜黑色素瘤/全身防控/替本福司/局部-全身协同/纳米医学Key words
uveal melanoma/metastatic uveal melanoma/systemic prevention and control/Tebentafusp/local-systemic synergy/nanomedicine引用本文复制引用
李晓蝶,刘超群,程晓娟,商雨寒,任瑞雪,何雨潞,杨小丽..葡萄膜黑色素瘤的治疗新进展[J].国际眼科杂志,2026,26(5):823-830,8.基金项目
川北医学院 2023 年度校级科研发展计划项目(No.CBY23-QDA33) 2023 School-level Scientific Research Project of North Sichuan Medical College(No.CBY23-QDA33) （No.CBY23-QDA33）
