国际眼科杂志2026，Vol.26Issue(5)：838-843,6.DOI:10.3980/j.issn.1672-5123.2026.5.18
甲状腺激素与眼病关系的研究进展
Relationship between thyroid hormones and eye diseases
摘要
Abstract
·Thyroid hormone(TH)is an iodinated derivative of the amino acid tyrosine secreted by the thyroid gland.It promotes glycolipid metabolism and is involved in various physiological and pathological processes by regulating cellular behaviors,such as cell proliferation,differentiation,and apoptosis.Recent studies have found that aberrant expression of TH in the orbit,retina,and sclera,and other ocular tissues can induce abnormal differentiation of orbital soft tissue adipocytes,alteration of retinal oxidative stress,and degradation of posterior scleral extracellular matrix(ECM),which contributes to the pathogenesis of many ophthalmic diseases,including Graves ophthalmopathy(GO),age-related macular degeneration(ARMD),diabetic retinopathy(DR),and myopia.This article reviews the role and mechanism of TH in various ophthalmic diseases,aiming to provide theoretical basis for the prevention and treatment of these ocular disorders.关键词
甲状腺激素/格雷夫斯眼病/视网膜疾病/眼表疾病/近视Key words
thyroid hormone/Graves ophthalmopathy/retinal diseases/ocular surface diseases/myopia引用本文复制引用
娄倩,孙龙娇,毕宏生,蒋文君..甲状腺激素与眼病关系的研究进展[J].国际眼科杂志,2026,26(5):838-843,6.基金项目
山东省重点研发计划项目(No.2021LCZX09) Key Research and Development Plan of Shandong Province(No.2021LCZX09) （No.2021LCZX09）
