南京中医药大学学报2026，Vol.42Issue(4)：609-615,7.DOI:10.14148/j.issn.1672-0482.2026.0609
补肾密骨片治疗脾肾两虚型少弱精子症的临床研究
Clinical Study of Bushen Migu Tablet in Treating Oligoasthenospermia with Spleen-Kidney Deficiency Syndrome
摘要
Abstract
OBJECTIVE To evaluate the clinical efficacy and safety of Bushen Migu Tablet in treating oligoasthenospermia with spleen-kidney deficiency syndrome.METHODS A total of 200 patients were randomly divided into an observation group(n=100)and a control group(n=100).The control group received levocarnitine oral solution combined with lifestyle interventions,while the observa-tion group received additional Bushen Migu Tablet.The treatment lasted for 12 weeks.Traditional Chinese medicine(TCM)syndrome scores were recorded before treatment,at 4 weeks,and at 12 weeks of treatment.Changes in semen parameters[semen volume,sperm den-sity,percentage of progressively motile sperm(PR),sperm viability,linear motility rate,and percentage of normal-morphological sperm]were detected using a computer-assisted semen analysis system.The clinical efficacy of the two groups was evaluated after treatment,and adverse drug reactions were monitored during the treatment period.RESULTS After 4 and 12 weeks of treatment,both groups showed significant increases in semen volume,sperm density,PR,sperm viability,linear motility rate,and the proportion of normal-morphological sperm(P<0.05).At 4 weeks of treatment,the observation group had higher sperm viability,linear motility rate,and the proportion of normal-morphological sperm than the control group(P<0.05).At 12 weeks of treatment,the observation group showed sig-nificantly higher semen volume,sperm density,PR,sperm viability,linear motility rate,and proportion of normal-morphological sperm compared to the control group(P<0.05);the efficacy of the observation group was significantly better than that of the control group(P<0.01).At 4 and 12 weeks of treatment,the observation group showed significant reductions in spontaneous sweating and loose stools,sore-ness and weakness of the waist and knees,low semen volume,decreased sexual desire,frequent nocturnal urination,and total score(P<0.05),with the observation group outperforming the control group(P<0.05).At 12 weeks of treatment,the observation group had lower scores in spontaneous sweating,loose stools,soreness and weakness of the waist and knees,low semen volume,frequent nocturnal urina-tion,and total score compared to 4 weeks of treatment(P<0.05).No significant adverse reactions were observed in either group during the treatment period.CONCLUSION Bushen Migu Tablet combined with levocarnitine significantly improves semen quality and TCM symptoms in patients with oligoasthenospermia and spleen-kidney deficiency syndrome,demonstrating good safety.关键词
少弱精子症/脾肾两虚证/补肾密骨片/左卡尼汀/精-髓-骨-生殖轴/异病同治/随机对照Key words
oligoasthenospermia/spleen-kidney deficiency syndrome/Bushen Migu Tablet/levocarnitine/essence-marrow-bone-reproductive axis/treating different diseases with the same method/randomized controlled分类
医药卫生引用本文复制引用
杭方杰,王骏,汤国庆,余琪伟,周宇,吴余凡..补肾密骨片治疗脾肾两虚型少弱精子症的临床研究[J].南京中医药大学学报,2026,42(4):609-615,7.基金项目
2025年度省中医药科技发展计划青年人才项目(QN202520) （QN202520）
