中国海洋大学学报（自然科学版）2026，Vol.56Issue(5)：113-119,7.DOI:10.16441/j.cnki.hdxb.20250135
AB3217A及其衍生物的模块化合成
Modular Synthesis of AB3217A and Its Derivatives
摘要
Abstract
A modular synthesisof AB3217A with antimite activity and its analogues has been achieved.The synthesis uses the readily accessible anisomycin and D-thioxylofuranoside derivative as the starting materials,and involves stereoselective β-xylofuranosidic bond construction directed by the neighboring group participation of the C2-benzoate in the xylofuranosyl residue,and a DDQ-promoted intramolecular cross-dehydrogenative etherification reaction as the key transformations.Through this integrated ap-proach,AB3217A and its structural analogues were successfully synthesized in 9 to 10 steps sequence with overall yields of 5.6%～8.9%,thereby establishing a foundation of material basis for biological evaluation in future.关键词
AB3217A/模块化全合成/分子内交叉脱氢醚化Key words
AB3217A/modular synthesis/intramolecular cross-dehydrogenative etherification分类
医药卫生引用本文复制引用
孙超民,王自强,王鹏,宋妮,李明..AB3217A及其衍生物的模块化合成[J].中国海洋大学学报（自然科学版）,2026,56(5):113-119,7.基金项目
国家自然科学基金项目(22377114) （22377114）
青岛海洋科技中心专项经费(2022QNLM030003-2)资助 Supported by the National Natural Science Foundation of China(22377114) （2022QNLM030003-2）
the Special Fund for Qingdao Marine Science and Tech-nology Center(2022QNLM030003-2) （2022QNLM030003-2）
