肿瘤预防与治疗2026，Vol.39Issue(4)：256-261,6.DOI:10.3969/j.issn.1674-0904.2026.04.002
子宫内膜癌的分子分型:对临床实践的影响和未来探索的问题
Molecular Classification of Endometrial Cancer:Implications for Clinical Practice and Questions for Future Exploration
摘要
Abstract
Molecular classification of endometrial cancer has become a new cornerstone of precision diagnosis and treat-ment.In 2013,The Cancer Genome Atlas project proposed four molecular subtypes:POLE ultramutated,microsatellite in-stability,copy-number low,and copy-number high.Simplified classification strategies such as ProMisE and TransPORTEC have made clinical application possible.Molecular classification has significant implications for preoperative surgical deci-sion-making,postoperative adjuvant therapy planning,fertility-sparing treatment,and Lynch syndrome screening.Howev-er,clinical application still faces challenges in testing accessibility,clinical prognostic heterogeneity,and interpretation of mixed molecular features.Future research should explore more convenient and accurate classification methods,establish secondary stratification systems for highly heterogeneous subtypes such as no specific molecular profile(NSMP),and vali-date classification-based treatment strategies through prospective clinical trials to ultimately construct a dynamic,precise,accessible new paradigm for comprehensive endometrial cancer management.关键词
子宫内膜癌/分子分型/临床实践/精准治疗Key words
Endometrial cancer/Molecular classification/Clinical practice/Precision therapy分类
医药卫生引用本文复制引用
彭澎,向阳..子宫内膜癌的分子分型:对临床实践的影响和未来探索的问题[J].肿瘤预防与治疗,2026,39(4):256-261,6.基金项目
十四五国家重点研发计划(编号:2025YFC2708301) This study was supported by National Key R&D Program of the 14th Five-Year Plan(No.2025YFC2708301). （编号:2025YFC2708301）
