肿瘤预防与治疗2026，Vol.39Issue(4)：306-314,9.DOI:10.3969/j.issn.1674-0904.2026.04.008
全身免疫炎症指数和全身炎症反应指数对卵巢癌术后1年内复发的预测价值
Predictive Value of the Systemic Immune-Inflammation Index and System-ic Inflammation Response Index for 1-Year Postoperative Recurrence in Ovarian Cancer
摘要
Abstract
Objective:To evaluate the predictive value of the systemic immune-inflammation index(SII)and systemic inflammatory response index(SIRI)for recurrence within one year after surgery in ovarian cancer,and to explore their clini-cal potential as biomarkers for recurrence risk assessment.Methods:Clinical data of 50 ovarian cancer patients who under-went surgical treatment at the Fourth Affiliated Hospital of Soochow University between January 2021 and November 2024 were retrospectively analyzed.Preoperative hematological parameters were collected to calculate SII(platelets×neutrophils/lymphocytes)and SIRI(neutrophils×monocytes/lymphocytes).Univariate analysis,multivariate logistic regression,and stratified analysis were used to assess the association between SII/SIRI and one-year postoperative recurrence,and the ROC curve and Hosmer-Lemeshow test were used to evaluate the predictive performance of the model.Results:Of the 50 pa-tients,15(30.00％)experienced recurrence within one year after surgery.Univariate analysis revealed that patients with FIGO stage III～IV had a significantly higher risk of recurrence than those with stage I～II(OR=5.24,95％CI:1.23～22.28,P=0.025),while neither SII nor SIRI showed a statistically significant association with recurrence within one year after surgery(Model 1).After adjusting for baseline characteristics such as age,menopausal status,gravidity,parity,and history of prior surgery(Model 2),the associations of SII(OR=2.32,95％CI:0.98～5.52,P=0.057)and SIRI(OR=2.18,95％CI:0.96～4.95,P=0.061)with one-year postoperative recurrence were not statistically significant.After further adjustment for factors such as extent of resection,FIGO stage,platinum-based adjuvant chemotherapy,and high-grade serous carcinoma status(Model 3),neither SII(OR=1.83,95％CI:0.70～4.78,P=0.215)nor SIRI(OR=2.02,95％CI:0.87～4.68,P=0.102)showed a statistically significant association with one-year postoperative recur-rence;the AUC of Model 3 was 0.861(95％CI:0.741～0.981),and the P-value for the goodness-of-fit test was 0.373.Subgroup analysis revealed that in postmenopausal patients,SII(OR=1.00,P=0.008)and SIRI(OR=4.56,P=0.012),and in patients who underwent R0 resection,SII(OR=1.00,P=0.005)and SIRI(OR=5.59,P=0.017),still demonstrated significant predictive value in one-year postoperative recurrence.Conclusion:This study indi-cates that SII and SIRI are significantly associated with the risk of one-year postoperative recurrence of ovarian cancer in specific subgroups(postmenopausal patients and those who underwent R0 resection),and may serve as supplementary in-dicators for assessing the risk of postoperative recurrence.However,in the overall population,their independent predictive value requires further validation in large-scale studies.These inflammatory markers,based on routine hematological param-eters,provide a simple and cost-effective tool for the precise assessment of the risk of one-year postoperative recurrence,aiding in the identification of high-risk patients and guiding the formulation of individualized treatment strategies.关键词
卵巢癌/全身免疫炎症指数/全身炎症反应指数/复发/预测因子Key words
Ovarian cancer/Systemic immune-inflammatory index/Systemic inflammatory response index/Recurrence/Predictive factors分类
医药卫生引用本文复制引用
靳鲁鸿媛,冯君,黄强,杨丹丹,侯文杰..全身免疫炎症指数和全身炎症反应指数对卵巢癌术后1年内复发的预测价值[J].肿瘤预防与治疗,2026,39(4):306-314,9.基金项目
2024 年苏州市卫生青年骨干人才"全国导师制"培训项目(编号:Qngg2024015) This study was supported by grants from Suzhou Mu-nicipal Health Commission(No.Qngg2024015). （编号:Qngg2024015）
