肿瘤预防与治疗2026，Vol.39Issue(4)：322-329,8.DOI:10.3969/j.issn.1674-0904.2026.04.010
免疫检查点抑制剂在妊娠滋养细胞肿瘤中的研究进展
Progress in Immune Checkpoint Inhibitors for Gestational Trophoblastic Tumors
摘要
Abstract
Gestational trophoblastic neoplasia(GTN)is caused by the abnormal development and proliferation of gesta-tional trophoblastic cells,and includes invasive mole,choriocarcinoma,placental site trophoblastic tumor,and epithelioid trophoblastic tumor.Although chemotherapy is the mainstream and effective initial treatment,with a complete cure rate of o-ver 80％,some patients develop drug resistance during treatment,leading to poor outcomes,treatment failure,and even death.Therefore,the management of drug-resistant and relapsed patients remains a clinical challenge.In recent years,im-mune checkpoint inhibitors(ICIs)have achieved major breakthroughs in oncology.The strategy of combining ICIs with chemotherapy offers a new approach for the treatment of GTN.Currently,there are few systematic reviews on the application of ICIs combined with chemotherapy in GTN.This review aims to systematically summarize the research progress of ICIs com-bined with chemotherapy and other treatment modalities,and to further elaborate on their mechanisms of action,efficacy,and safety.Additionally,this article will discuss the prospects of ICIs combined with other treatment strategies and future re-search directions,with the goal of providing references for clinical practice and subsequent studies.关键词
妊娠滋养细胞肿瘤/免疫检查点抑制剂/免疫治疗/联合治疗/耐药Key words
Gestational trophoblastic neoplasia/Immune checkpoint inhibitors/Immunotherapy/Combination therapy/Drug resistance分类
医药卫生引用本文复制引用
曾懿汇,陈丽华,王淑玲,余玉枚,高乔,吴齐斌..免疫检查点抑制剂在妊娠滋养细胞肿瘤中的研究进展[J].肿瘤预防与治疗,2026,39(4):322-329,8.基金项目
This study was supported by grants from Health Commission of Fujian Province(No.2024J011056,No.2020Y9162). 福建省自然科学基金项目(编号:2024J011056) （No.2024J011056,No.2020Y9162）
福建省科技创新联合资金项目(编号:2020Y9162) （编号:2020Y9162）
