首都师范大学学报（自然科学版）2026，Vol.47Issue(2)：86-93,8.DOI:10.19789/j.1004-9398.2026.02.013
吡啶离子液体绿色化学催化剂设计及教学实践:乙酸乙酯合成实验中的创新能力培养
Design and teaching practice of pyridine ionic liquid green chemical catalysts:cultivation of innovation ability in the synthesis experiment of ethyl acetate
摘要
Abstract
Addressing the issues of equipment corrosion,waste acid pollution,and difficult-to-control side reactions caused by the use of concentrated H2SO4 as a catalyst in the traditional synthesis process of ethyl acetate,this study developed a green catalytic system of N-butylpyridinium bromide ionic liquid and established a"ionic liquid catalysis-inquiry experiment"dual-drive teaching model.Using n-bromobutane as a raw material,N-butylpyridinium bromide ionic liquid was synthesized through the quaternization reaction of pyridine,and its structure was determined using infrared spectroscopy and proton nuclear magnetic resonance technology.By adjusting the reaction temperature,time,and amount of catalyst,the catalytic activity,selectivity,and cyclic stability of this catalytic system were studied.The results showed that when 15 mmol of ionic liquid reacted at 135℃for 90 min,the yield was 52.3%,and the catalyst could be stably recycled 5 times.The optimized catalytic system was superior to the traditional process in terms of product yield,purity,and cyclic usability of the catalyst,and the separation and recovery process of the catalyst was simple,effectively reducing environmental pollution.In teaching,the method of"molecular design-process innovation-teaching reconstruction"was adopted to guide students in designing ionic liquid catalysts to replace concentrated H2SO4 and achieve green synthesis of ethyl acetate.By optimizing reaction conditions,mastering multivariable regulation and spectrum analysis methods.Reconstructing inquiry experimental procedures,enhancing experimental design capabilities and green chemistry cognition,and promoting the transformation of traditional experiments to integrated,innovative teaching.This study not only realized the green upgrade of experimental processes,but also integrated scientific research achievements into teaching practice,helping students build systematic scientific research thinking,providing a new path that can be promoted for the reform of chemistry experimental courses.关键词
吡啶离子液体/乙酸乙酯/有机化学实验/创新能力培养/绿色化学Key words
pyridine ionic liquid/ethyl acetate/organic chemistry experiments/innovation ability training/green chemistry分类
化学化工引用本文复制引用
张璐莹,卢思嫄,薛雨婷,杨莹,王前,方玉,李凯,郑婷婷..吡啶离子液体绿色化学催化剂设计及教学实践:乙酸乙酯合成实验中的创新能力培养[J].首都师范大学学报（自然科学版）,2026,47(2):86-93,8.基金项目
首都师范大学关于人工智能赋能课程建设项目 （）
