药学研究2026，Vol.45Issue(3)：290-294,5.DOI:10.13506/j.cnki.jpr.2026.03.007
石笔木不同部位提取物体外降血糖功效的比较
Comparison of hypoglycemic effect of extracts from different parts of Tutcheria austrosinica in vitro
孙雅如 1司展 1李夏冉 1王柳 1袁少义 2袁漫彬 2史丽颖1
作者信息
- 1. 大连大学生命健康学院,辽宁大连 116622
- 2. 广东南多万金农业发展有限公司,广东揭阳 515526
- 折叠
摘要
Abstract
Objective To explore the α-glucosidase inhibitory activities of the extracts of different parts of Tutcheria austrosinica,the ethanol extracts and water extracts of the flowers,stamens,leaves,pericarps and seeds of T.austrosinica were prepared by refluxing extraction.Methods The α-glucosidase inhibitory activities of 10 kinds of extracts were screened with 4-nitrophenyl-D-glucopyranoside(PNPG)as substrate,the kinetics of active extracts was studied by enzyme-catalyzed reaction,and the Lineweaver-Burk curve was drawn to deduce their inhibitory types.Results The extracts of flowers,stamens,pericarps and seeds showed potent α-glucosidase inhibitory activities,and the inhibitory activity of the extract from the stamens was relatively high,with an IC50 value of 1.30 μg·mL-1.Inhibition dynamics analysis showed that the extracts of flowers,stamens,pericarps and seeds were all close to mixed modes of inhibition against α-glucosidase.Conclusion The extracts of flowers,stamens,pericarps and seeds of T.austrosinica exhibited promising α-glucosidase inhibitory activities.关键词
石笔木/α-葡萄糖苷酶/抑制剂Key words
Tutcheria austrosinica/α-Glucosidase/Inhibitors分类
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孙雅如,司展,李夏冉,王柳,袁少义,袁漫彬,史丽颖..石笔木不同部位提取物体外降血糖功效的比较[J].药学研究,2026,45(3):290-294,5.
