山东医药2026，Vol.66Issue(3)：10-14,5.DOI:10.3969/j.issn.1002-266X.2026.03.003
胃腺癌组织自噬相关基因13蛋白表达变化及其对患者预后的影响
Expression changes of ATG13 protein in gastric adenocarcinoma tissues and its effect on prognosis of patients
摘要
Abstract
Objective To investigate the expression changes of autophagy-related gene 13(ATG13)protein in gastric adenocarcinoma tissues and to analyze its effect on prognosis of patients.Methods Immunohistochemistry(IHC)was performed to assess ATG13 protein expression in 99 cases of primary gastric adenocarcinoma biopsy tissues and in 71 cases of adjacent tissues.ATG13 protein expression was compared among patients with different clinicopathological characteristics.Kaplan-Meier survival analysis was used to compare overall survival(OS)between patients with high and low ATG13 ex-pression.In addition,a Cox proportional hazards regression model was applied to identify risk factors for poor prognosis in patients with gastric adenocarcinoma.Results The high-expression rate of ATG13 protein was significantly higher in the gastric adenocarcinoma tissues than in the adjacent tissues(P＜0.05).Compared with patients with low ATG13 expression,those with high ATG13 expression had a larger maximum tumor diameter(P＜0.05).No significant differences were found between the two groups in age,sex,depth of tumor invasion,lymph node metastasis,distant metastasis,clinical stage,or pathological grade(all P＞0.05).Kaplan-Meier survival analysis indicated that OS was shorter in patients with high ATG13 expression than in those with low ATG13 expression(P＜0.05).Univariate Cox regression analysis showed that clinical stage,lymph node metastasis,distant metastasis,and ATG13 expression were associated with poor prognosis(all P＜0.05).Multivariate Cox regression analysis further demonstrated that distant metastasis and high ATG13 expression were in-dependent risk factors for poor prognosis in patients with gastric adenocarcinoma(all P＜0.05).Conclusion ATG13 pro-tein is highly expressed in gastric adenocarcinoma tissues,and high ATG13 expression is closely associated with poor prog-nosis in patients with gastric adenocarcinoma.关键词
自噬相关基因13/胃肿瘤/胃腺癌/预后不良Key words
autophagy-related gene 13/stomach neoplasms/gastric carcinoma/poor prognosis分类
医药卫生引用本文复制引用
黎甜甜,冶正财,冯钰迪,游颜杰,李文梅..胃腺癌组织自噬相关基因13蛋白表达变化及其对患者预后的影响[J].山东医药,2026,66(3):10-14,5.基金项目
宁夏回族自治区中央引导地方科技发展专项(2024FRD05094). （2024FRD05094）
