上海交通大学学报（医学版）2026，Vol.46Issue(4)：486-495,10.DOI:10.3969/j.issn.1674-8115.2026.04.008
成人高尿酸血症与代谢综合征的关联研究
Association between hyperuricemia and metabolic syndrome in adults
摘要
Abstract
Objective·To analyze the prevalence of hyperuricemia(HUA)and its correlation with metabolic syndrome(MS)and MS components among adults in the Ningbo Hangzhou Bay area of Zhejiang Province.Methods·A cross-sectional study was conducted among adults who underwent health examinations at Ningbo Hangzhou Bay Hospital from January to December 2022.Demographic data and clinical examination results were collected.The prevalence of HUA was calculated based on serum uric acid(SUA)levels.The estimated glomerular filtration rate(eGFR)was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation.MS was defined according to body mass index(BMI),blood pressure,fasting blood glucose,triglycerides(TG),and high-density lipoprotein cholesterol(HDL-C).The association between HUA and MS,as well as its individual components,was analyzed.Results·A total of 9 196 adults were included,with a mean age of(34.3±11.8)years;75.2%were males.The mean SUA level was(371.8±95.6)μmol/L,and the overall prevalence of HUA was 31.3%.Compared with the non-HUA group,the HUA group demonstrated a higher proportion of males,younger age,lower eGFR,and a higher prevalence of MS(all P<0.001).Regarding MS components,the HUA group showed significantly higher BMI,blood pressure,and TG levels,along with lower HDL-C levels(all P<0.001).Patients with MS had significantly higher SUA levels and a higher prevalence of HUA compared to those without MS(both P<0.001).Furthermore,both SUA levels and the prevalence of HUA increased progressively with the increasing number of MS components present.Multivariable Logistic regression analysis identified male sex(OR=3.74,95%CI 3.12‒4.48),younger age(per 5-year decrease,OR=1.22,95%CI 1.19‒1.26),eGFR<90 mL/(min·1.73 m2)(OR=2.45,95%CI 2.11‒2.84),BMI≥25 kg/m2(OR=2.31,95%CI 2.06‒2.60),elevated blood pressure(OR=1.18,95%CI 1.04‒1.32),TG≥1.7 mmol/L(OR=2.08,95%CI 1.81-2.37),and low HDL-C(OR=1.33,95%CI 1.15‒1.55)as independent risk factors for HUA.Conclusion·The prevalence of HUA is high among the adult population in the Ningbo Hangzhou Bay area.Male sex,younger age,decreased renal function,and the presence of MS components are risk factors for HUA in this population,with the prevalence increasing as the number of MS components accumulates.关键词
高尿酸血症/代谢综合征/肥胖/高血压/血脂异常Key words
hyperuricemia(HUA)/metabolic syndrome(MS)/obesity/hypertension/dyslipidemia分类
医药卫生引用本文复制引用
陆博涵,胡翠容,王瑾堃,陆继芳,金海姣,王玲,姜娜,牟姗..成人高尿酸血症与代谢综合征的关联研究[J].上海交通大学学报（医学版）,2026,46(4):486-495,10.基金项目
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科项目(GWVI-11.1-19) （2023-2025年）
国家自然科学基金(81970574,82170685,82370743). Key Disciplines Project of Shanghai Three-year Action Plan for Strengthening Public Health System Construction(2023-2025)(GWVI-11.1-19) （81970574,82170685,82370743）
National Natural Science Foundation of China(81970574,82170685,82370743). （81970574,82170685,82370743）
