摘要
Abstract
Objective·To investigate the physiological distribution characteristics of fluorine-18 fluorodeoxyglucose(18F-FDG)in the liver background and mediastinal blood pool on positron emission tomography/computed tomography(PET/CT)in children and adolescents,and to analyze the influencing factors.Methods·A total of 271 pediatric patients(<18 years)with pathologically confirmed or suspected malignant tumors were retrospectively analyzed.Patients were divided into four age groups:≤2 years,3‒5 years,6-10 years,and≥11 years.The maximum standardized uptake value and mean standardized uptake value(SUVmax and SUVmean)of the liver and mediastinal blood pool were measured.Their associations with age,weight,height,body mass index(BMI),gender,liver function,and chemotherapy status were assessed.Results·The SUVmax and SUVmean of the liver were 1.89±0.62 and 1.36±0.44,respectively.The mediastinal blood pool SUVmax and SUVmean were 1.11±0.37 and 0.98±0.32.Pearson correlation analysis showed that SUVmax and SUVmean values of the liver and mediastinal blood pool were significantly positively correlated(r=0.78‒0.86,P<0.001).All SUV parameters were positively correlated with age,weight,height,and BMI(r=0.47‒0.73,P<0.05),but showed no significant correlation with gender(r=0.02‒0.04,P>0.05).18F-FDG uptake in both the liver and mediastinal blood pool increased significantly with age.Hepatic SUVmax increased from 1.41±0.32 in the≤2-year group to 2.57±0.60 in the≥11-year group(P<0.001),while mediastinal SUVmax increased from 0.91±0.27 to 1.42±0.41(P<0.001).Children with abnormal liver function had lower hepatic uptake compared to those with normal liver function(1.71±0.61 vs 1.93±0.61,P=0.034),while no significant difference was observed before and after chemotherapy.Multivariate regression analysis identified weight and age as independent influencing factors for hepatic SUV values(P<0.001),and body weight had the greatest impact on mediastinal blood pool SUV values(P<0.001).Conclusion·Hepatic background and mediastinal blood pool 18F-FDG uptake increases with age and weight in children and adolescents,with SUV values typically below 2 in children under 5 years old.The SUV values of the liver and mediastinal blood pool show good consistency and reproducibility as non-target reference parameters for therapeutic response evaluation in pediatric PET/CT,which may improve the accuracy and standardization of image interpretation.关键词
儿童与青少年/正电子发射断层成像/计算机断层显像/氟-18标记的氟代脱氧葡萄糖/肝脏本底/纵隔血池/标准化摄取值Key words
children and adolescents/positron emission tomography/computed tomography/18F-FDG/liver background/mediastinal blood pool/standardized uptake value(SUV)分类
医药卫生
