上海中医药杂志2026，Vol.60Issue(5)：77-85,9.DOI:10.16305/j.1007-1334.2026.z20250924007
中药单体调控JAK/STAT信号通路干预椎间盘退变的研究进展
Research progress on regulation of JAK/STAT signaling pathway by bioactive monomers in Chinese materia medica for intervention in intervertebral disc degeneration
摘要
Abstract
This article reviews various bioactive monomers derived from Chinese materia medica,such as myricetin,anthocyanins,salvianolic acid B,resveratrol,salidroside,cryptotanshinone,and anisodamine.These monomers can significantly ameliorate the pathological changes of intervertebral disc degeneration(IVDD)through regulating the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway.Specifically,they modulate the protein levels of phosphorylated JAK(p-JAK)and phosphorylated STAT(p-STAT),downregulate inflammatory cytokines and matrix-degrading enzymes,promote the synthesis of extracellular matrix,and enhance autophagy and antioxidant capacity,significantly improve the pathological changes of intervertebral disc degeneration.关键词
椎间盘退变/腰痛/中药单体/Janus酪氨酸蛋白激酶/信号转导及转录活化因子/作用机制Key words
intervertebral disc degeneration/lumbodynia/Chinese materia medica monomers/Janus kinase/signal transducer and activator of transcription/mechanism of action引用本文复制引用
杨龙,郭铁峰,刘晏东,李军杰,罗林钊,郭洁,左鹏,张彦军..中药单体调控JAK/STAT信号通路干预椎间盘退变的研究进展[J].上海中医药杂志,2026,60(5):77-85,9.基金项目
国家自然科学基金项目(82360947) （82360947）
国家中医药管理局重大疑难疾病中西医临床协作项目(ZDYN-2024-A-145) （ZDYN-2024-A-145）
甘肃省卫健委卫生健康行业科技创新重大科研项目(GSWSZD2024-04) （GSWSZD2024-04）
2024年甘肃省委组织部省级人才项目(甘组通字:2024-4) （甘组通字:2024-4）
