上海中医药杂志2026，Vol.60Issue(5)：86-91,6.DOI:10.16305/j.1007-1334.2026.z20250914003
基于肠道菌群探讨中药防治骨关节炎研究进展
Research progress in Chinese materia medica for osteoarthritis prevention and treatment based on gut microbiota
摘要
Abstract
Osteoarthritis(OA)is a common disabling joint disease in orthopedics.The occurrence and progression of OA are closely associated with gut microbiota and their metabolites.Chinese materia medica(CMM)is characterized by its multi-component,multi-target and multi-pathway therapeutic effects,serving as an important strategy for OA treatment.By reviewing relevant research findings,this paper starts with the correlation between gut microbiota,their metabolites and OA,discusses the preventive and therapeutic effects and mechanisms of CMM on OA from the perspectives of inflammation mediation and immune homeostasis,and improves the"CMM-microbiota-inflammation"regulatory network,aiming to provide a theoretical reference for subsequent clinical translation.关键词
骨关节炎/肠道菌群/中药/作用机制/炎症/免疫/研究进展Key words
osteoarthritis/gut microbiota/Chinese materia medica/mechanism of action/inflammation/immunity/research progress引用本文复制引用
张嘉,邢涛,姚兴璋,姚辉,李冰霞,夏吉杰,杨荣,赵庆基..基于肠道菌群探讨中药防治骨关节炎研究进展[J].上海中医药杂志,2026,60(5):86-91,6.基金项目
甘肃省科技厅联合科研基金一般项目(23JRRA1533) （23JRRA1533）
甘肃省中医药管理局高水平重点管理课题(GZKZ-2024-7) （GZKZ-2024-7）
甘肃省药品监督管理局科技项目(2023GSMPA044) （2023GSMPA044）
