上海中医药杂志2026，Vol.60Issue(5)：92-100,9.DOI:10.16305/j.1007-1334.2026.z20250902004
中药调控NLRP3炎症小体防治炎症性肠病"炎-癌"转化作用机制研究进展
Research progress on mechanism of traditional Chinese medicine regulating NLRP3 inflammasome in preventing and treating"inflammation-cancer"transformation of inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD)is a chronic recurrent inflammatory disorder,whose long-term pathological process is closely associated with colorectal cancer,involving the core mechanism of"inflammation-cancer"transformation.NOD-like receptor protein 3(NLRP3)plays a crucial role in inflammatory responses,and its abnormal activation is closely related to the pathogenesis of various inflammatory diseases and tumors.By systematically reviewing the core role of the NLRP3 inflammasome in the"inflammation-cancer"transformation of IBD,this paper summarizes the research progress on traditional Chinese medicine intervening the pathological process of IBD through regulating the NLRP3 inflammasome.It aims to provide references for subsequent related mechanism research and clinical interventions.关键词
炎症性肠病/结直肠癌/"炎-癌"转化/炎症小体/中药/作用机制Key words
inflammatory bowel disease/colorectal cancer/"inflammation-cancer"transformation/inflammasome/Chinese materia medica/mechanism of action引用本文复制引用
马丽,张丽娜,李生财,万斌,李彦龙..中药调控NLRP3炎症小体防治炎症性肠病"炎-癌"转化作用机制研究进展[J].上海中医药杂志,2026,60(5):92-100,9.基金项目
甘肃省自然科学基金项目(21JR11RA205) （21JR11RA205）
甘肃省科技厅青年科技基金计划项目(18JR3RA072) （18JR3RA072）
甘肃省第二批陇原青年英才项目(中共甘肃省委人才工作领导小组[2023]11号) （中共甘肃省委人才工作领导小组[2023]11号）
敦煌医学与转化教育部重点实验室开放课题(DHYX18-18) （DHYX18-18）
2024年度甘肃省中医药科研立项课题(GZKG-2024-44) （GZKG-2024-44）
