生物技术进展2026，Vol.16Issue(2)：215-224,10.DOI:10.19586/j.2095-2341.2026.0017
先进水凝胶传感平台的理性设计策略
Rational Design Strategies for Advanced Hydrogel-based Sensing Platforms
摘要
Abstract
Sensing technology serves as a cornerstone for health and environmental monitoring,yet its advancement is con-strained by the inadequate biocompatibility and mechanical compatibility of traditional interface materials.Hydrogels,as a class of hydrophilic three-dimensional network soft materials,offer an ideal platform to address this bottleneck owing to their biomimet-ic features and tunable physicochemical properties.For the first time,this review systematically summarized and elaborated on eight rational design paradigms for hydrogel-based sensors,including functional nucleic acid programming,enzymatic catalysis and biomolecular recognition,synthetic supramolecular modules,nanocomposite integration,physical confinement effects,stim-ulus-responsive polymer systems,microneedle-based sensing,and flexible wearable device integration.These paradigms clarified the central role of hydrogels as either active responsive units or passive optimization matrices across different strategies.The work aims to provide a systematic rational design framework for relevant research,facilitating a paradigm shift in the field from empiri-cal exploration toward rational construction.关键词
水凝胶/传感器/检测/理性设计Key words
hydrogel/sensor/detection/rational design分类
生物科学引用本文复制引用
粟元,焦伟伟,朱龙佼,许文涛..先进水凝胶传感平台的理性设计策略[J].生物技术进展,2026,16(2):215-224,10.基金项目
北京市设施蔬菜创新团队项目(BAIC01) （BAIC01）
北京市自然科学基金资助项目(L244077) （L244077）
国中康健集团科技项目(GZKJ-KJXX-QTHT-20230626). （GZKJ-KJXX-QTHT-20230626）
