生物技术进展2026，Vol.16Issue(2)：318-326,9.DOI:10.19586/j.2095-2341.2025.0183
肝细胞癌中的线粒体改变及其靶向治疗研究进展
Mitochondrial Alterations in Hepatocellular Carcinoma and Advances in Targeted Therapeutics
韩雪奇 1高佩娴 1张旭娟 2赵鹏翔 1刘梦昱1
作者信息
- 1. 北京工业大学化学与生命科学学院,北京 100124
- 2. 北京工业大学材料科学与工程学院,北京 100124
- 折叠
摘要
Abstract
Hepatocellular carcinoma(HCC)is a malignancy associated with high global incidence and mortality rates,whose de-velopment and progression are closely linked to metabolic dysregulation.As central hubs for cellular energy metabolism and sig-naling,mitochondria undergo extensive and complex remodeling in HCC,profoundly influencing tumor initiation,progression,and therapeutic response.However,the specific mechanisms underlying these mitochondrial changes and their exact roles in HCC pathogenesis remain incompletely elucidated,which has,to a certain extent,impeded the development and clinical appli-cation of mitochondria-targeted therapeutics for HCC.This review systematically summarized mitochondrial alterations in HCC from three key dimensions:metabolic reprogramming,oxidative stress and mitochondrial DNA(mtDNA)damage,and dysregu-lation of mitochondrial dynamics.It further elucidated the mechanisms by which these alterations drive HCC development and treatment response.Additionally,the review consolidated and prospected the current progress on mitochondria-targeted therapeu-tic strategies for HCC,aiming provide theoretical foundation and novel insights for future basic research and clinical interven-tions in the treatment of HCC.关键词
肝细胞癌/线粒体/线粒体动力学/靶向治疗Key words
hepatocellular carcinoma/mitochondria/mitochondrial dynamics/targeted therapeatics分类
生物科学引用本文复制引用
韩雪奇,高佩娴,张旭娟,赵鹏翔,刘梦昱..肝细胞癌中的线粒体改变及其靶向治疗研究进展[J].生物技术进展,2026,16(2):318-326,9.
