生物技术进展2026，Vol.16Issue(2)：338-347,10.DOI:10.19586/j.2095-2341.2025.0162
阻塞性睡眠呼吸暂停与肠道菌群相互作用的研究进展
Research Progress on Reciprocal Interactions Between Obstructive Sleep Apnea and Gut Microbiota
摘要
Abstract
Obstructive sleep apnea(OSA)is a common chronic sleep-related breathing disorder,characterized primarily by in-termittent hypoxia and sleep fragmentation resulting from the recurrent collapse of the upper airway during sleep.Studies indicat-ed that disturbances of the gut microbiota represent a crucial intermediary mechanism in the multi-system pathological damage and development of comorbidities induced by OSA.Changes in the gut microbiota under OSA conditions,including abnormalities in α/β diversity,enrichment of anaerobic bacteria,reduction in short-chain fatty acid-producing bacteria,as well as alterations in metabolic profiles such as bile acids,amino acids,and fatty acids,were systematically elucidated.Furthermore,the key driv-ing role of gut microbiota and their metabolites in OSA-related comorbidities,such as hypertension and atherosclerosis,was ex-tensively investigated.Concurrently,research progress on intervention strategies targeting the gut microbiome was comprehen-sively integrated.These findings provide new perspectives and a foundation for mechanistic research and clinical management of OSA.关键词
阻塞性睡眠呼吸暂停/肠道菌群/代谢物/高血压/动脉粥样硬化Key words
obstructive sleep apnea/gut microbiota/metabolites/hypertension/atherosclerosis分类
生物科学引用本文复制引用
祁晶,吕秀云..阻塞性睡眠呼吸暂停与肠道菌群相互作用的研究进展[J].生物技术进展,2026,16(2):338-347,10.基金项目
内蒙古自治区自然科学基金联合项目(2025LHMS08072). （2025LHMS08072）
