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Establishing Komagataella phaffii as a cell factory for efficient production of chondroitin sulfate

Binying Lv Feng Xiao Yingjia Pan Dongfang Li Jine Li Chang Dong Lei Huang Zhinan Xu Jiazhang Lian

生物设计研究（英文）2026，Vol.8Issue(1)：10-19,10.

生物设计研究（英文）2026，Vol.8Issue(1)：10-19,10.DOI:10.1016/j.bidere.2025.100062

Establishing Komagataella phaffii as a cell factory for efficient production of chondroitin sulfate

Binying Lv ¹Feng Xiao ²Yingjia Pan ¹Dongfang Li ²Jine Li ³Chang Dong ¹Lei Huang ¹Zhinan Xu ⁴Jiazhang Lian⁵

作者信息

1. Key Laboratory of Biomass Chemical Engineering of Ministry of Education&State Key Laboratory of Biobased Transportation Fuel Technology,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,310027,China||ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,310000,China
2. ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,310000,China
3. State Key Laboratory of Microbial Diversity and Innovative Utilization,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China
4. Key Laboratory of Biomass Chemical Engineering of Ministry of Education&State Key Laboratory of Biobased Transportation Fuel Technology,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,310027,China
5. Key Laboratory of Biomass Chemical Engineering of Ministry of Education&State Key Laboratory of Biobased Transportation Fuel Technology,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,310027,China||ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,310000,China||State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,210093,China
折叠

摘要

关键词

Chondroitin sulfate A/Chondroitin-4-O-Sulfotransferase/3′-phosphoadenosine-5′-phosphosulfate/Synthetic biology/Komagataella phaffii

Key words

Chondroitin sulfate A/Chondroitin-4-O-Sulfotransferase/3′-phosphoadenosine-5′-phosphosulfate/Synthetic biology/Komagataella phaffii

引用本文复制引用

Binying Lv,Feng Xiao,Yingjia Pan,Dongfang Li,Jine Li,Chang Dong,Lei Huang,Zhinan Xu,Jiazhang Lian..Establishing Komagataella phaffii as a cell factory for efficient production of chondroitin sulfate[J].生物设计研究（英文）,2026,8(1):10-19,10.

基金项目

This work was supported by the National Key Research and Devel-opment Program of China(2021YFC2103200)and the National Natural Science Foundation of China(32300053,22278361 and 22478341),the Fundamental Research Funds for the Central Universities(226-2025-00044),A Project Supported by Scientific Research Fund of Zhejiang Provincial Education Department(Y202457170),and Open Research Fund of State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing University.iBioFoundry and Core Facility at ZJU-Hangzhou Global Scientific and Technological Innovation Center were acknowledged for analytical support. （2021YFC2103200）

生物设计研究（英文）

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