生物设计研究（英文）2026，Vol.8Issue(1)：39-57,19.DOI:10.1016/j.bidere.2025.100044
From machine learning to multimodal models:The AI revolution in enzyme engineering
From machine learning to multimodal models:The AI revolution in enzyme engineering
Ziyan Shi 1Jianing Wang 2Yanhui Gu 3Junsheng Zhou 3Hao Zhou 4Shuaiqi Meng 5Haiyang Cui 5Shuping Xu 5Sihan Xue 5Kaiming Chen 6Yifan Lu 7Feiyue Wang 8Siyu Long 4Yannan Tian 9Peng Zhang2
作者信息
- 1. State Key Laboratory of Microbial Technology,College of Life Sciences,Nanjing Normal University,Nanjing,210097,China||Ministry of Education Key Laboratory of NSLSCS,Nanjing Normal University,Nanjing,210097,China||School of Computer and Electronic Information/School of Artificial Intelligence,Nanjing Normal University,Nanjing,210097,China
- 2. State Key Laboratory of Microbial Technology,Shandong University,No.72 Binhai Road,Qingdao,Shandong,266237,China
- 3. School of Computer and Electronic Information/School of Artificial Intelligence,Nanjing Normal University,Nanjing,210097,China
- 4. Institute for AI Industry Research,Tsinghua University,Beijing,100084,China
- 5. State Key Laboratory of Microbial Technology,College of Life Sciences,Nanjing Normal University,Nanjing,210097,China||Ministry of Education Key Laboratory of NSLSCS,Nanjing Normal University,Nanjing,210097,China
- 6. State Key Laboratory of Microbial Technology,College of Life Sciences,Nanjing Normal University,Nanjing,210097,China||School of Chemistry and Materials Science,Nanjing Normal University,Nanjing,210097,China
- 7. State Key Laboratory of Microbial Technology,College of Life Sciences,Nanjing Normal University,Nanjing,210097,China
- 8. College of Marine Science and Engineering,Nanjing Normal University,Nanjing,210097,China
- 9. Department of Systems Biology,School of Life Sciences,Southern University of Science and Technology,No.1088 Xueyuan Avenue,Shenzhen,518055,China||Institute for Biological Electron Microscopy,Southern University of Science and Technology,No.1088 Xueyuan Avenue,Shenzhen,518055,Guangdong,China
- 折叠
摘要
关键词
Machine learning/Enzyme engineering/Enzyme function/Artificial intelligence/Protein language modelKey words
Machine learning/Enzyme engineering/Enzyme function/Artificial intelligence/Protein language model引用本文复制引用
Ziyan Shi,Jianing Wang,Yanhui Gu,Junsheng Zhou,Hao Zhou,Shuaiqi Meng,Haiyang Cui,Shuping Xu,Sihan Xue,Kaiming Chen,Yifan Lu,Feiyue Wang,Siyu Long,Yannan Tian,Peng Zhang..From machine learning to multimodal models:The AI revolution in enzyme engineering[J].生物设计研究（英文）,2026,8(1):39-57,19.基金项目
This work was supported by the Coal-Major Project(Grant No.2025ZD1701600),National Natural Science Foundation of China(Grant No.22008166),Innovative Research Group Project of the National Natural Science Foundation of China(Grant No.22478199)and the Jiangsu Basic Research Center for Synthetic Biology(Grant No.BK20233003).This work is supported by Jiangsu Province"Entrepre-neurship and Innovation Plan"Education Fund(No.164080H00250),Research Start-up Fund of Nanjing Normal University(No.184080H201B94),the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,No.164320H1865).Icon graphics of this work were supported by BioRender.com.And partial data analysis is supported by Ministry of Education Key Laboratory of NSLSCS. （Grant No.2025ZD1701600）
