生物信息学2026，Vol.24Issue(1)：23-31,9.DOI:10.12113/202407006
Sestrin1蛋白的结构及功能预测分析
Predictive analysis of the structure and function of the Sestrin1 protein
摘要
Abstract
To predict the structure and function of the Sestrin1 protein,bioinformatics methods are used to analyze its physicochemical properties,secondary structure,tertiary structure,protein interactions and functions.The results show that Sestrin1 is an unstable intracellular hydrophilic protein,lacking signal peptides and transmembrane regions,and can undergo phosphorylation modification.Its secondary structure is predominantly α-helical,with SESN-A and SESN-C as the main functional domains.It exerts antioxidant effects through the residues Cys130,Asp418 and Asp419.This study provides a theoretical basis for further exploring the role of the Sestrin1 protein in the development of high-altitude polycythemia.关键词
Sestrin1/理化性质/蛋白结构功能预测/蛋白质相互作用网络Key words
Sestrin1/Physicochemical properties/Protein structure and function prediction/Protein interaction network分类
生物科学引用本文复制引用
邵勇,宋昊云,刘芳..Sestrin1蛋白的结构及功能预测分析[J].生物信息学,2026,24(1):23-31,9.基金项目
青海省科技厅基础研究计划应用基础研究项目(No.2022-ZJ-720). （No.2022-ZJ-720）
