石油化工2026，Vol.55Issue(4)：483-489,7.DOI:10.3969/j.issn.1000-8144.2026.04.001
钙法Cannizzaro合成三羟甲基丙烷反应研究
Synthesis of trimethylolpropane via Cannizzaro reaction with calcium method
摘要
Abstract
The reaction process of trimethylolpropane(TMP)synthesis from formaldehyde and n-butyraldehyde via the Cannizzaro reaction with calcium method was optimized.Orthogonal experiments were first conducted to identify the key factors influencing TMP yield,followed by single-factor experiments to determine the optimal reaction conditions.Meanwhile,the reaction process was systematically investigated using GC-MS characterization and the peak height increment method,and the reaction mechanism was analyzed.The results show that the optimal conditions for TMP synthesis via the Cannizzaro reaction with calcium method are n(n-butyraldehyde)∶n(calcium hydroxide)∶n(formaldehyde)=1∶0.475∶3.5,the reaction temperature of 45℃,and the reaction time of 90 min.Under these conditions,the TMP yield reaches 91.6%,with good product color and no yellowing observed.The reaction pathway and the possible by-products are also identified,indicating that the self-aldol condensation of n-butyraldehyde was the main source of by-products.关键词
氢氧化钙/催化/正交实验/优化/稳定性Key words
calcium hydroxide/catalysis/orthogonal experiment/optimization/stability分类
化学化工引用本文复制引用
Erdenetsetseg Davaanyam,丁同梅,杨秀国,叶陆仟,李鸿雁,张书宇..钙法Cannizzaro合成三羟甲基丙烷反应研究[J].石油化工,2026,55(4):483-489,7.基金项目
内蒙古自治区赤峰市2022年度区域协同创新平台科技合作项目(2022sj002) （2022sj002）
赤峰瑞阳化工有限公司横向项目(23H010101303). （23H010101303）
