实用医学杂志2026，Vol.42Issue(8)：1341-1346,6.DOI:10.3969/j.issn.1006-5725.2026.08.005
肺动脉搏动指数联合心肌微循环指标对老年慢性射血分数降低心力衰竭患者主要不良心血管事件的预测价值
Predictive value of combined pulmonary artery pulsatility index and myocardial microcirculation indicators for major adverse cardiovascular events in elderly patients with chronic heart failure with reduced ejection fraction
摘要
Abstract
Objective To investigate the prognostic value of combined assessment of the pulmonary artery pulsatility index(PAPi)and the myocardial microcirculation index in elderly patients with chronic heart failure with reduced ejection fraction(HFrEF).Methods From January 2024 to January 2025,108 elderly HFrEF patients were enrolled,with the mean age of(72.37±6.54)years.Patients underwent a 6-month follow-up period,and the occurrence of major adverse cardiovascular events(MACE)was recorded.Clinical characteristics,hemodynamic parameters and myocardial microcirculation index were compared between MACE and non-MACE groups.Independent risk factors for MACE were identified using multivariate logistic regression,and receiver operating characteristic(ROC)curve was employed to assess predictive performance.Results During follow-up,32 patients(29.63％)experienced MACE.Compared with the non-MACE group,the MACE group exhibited significantly higher age and atrial fibrillation incidence(P＜0.05).The MACE group had lower PAPi but higher total myocardial ischemia burden and CSI scores than the non-MACE group(P＜0.05).Multivariate logistic regression identified PAPi,total myocardial ischemia burden,and CSI score as independent predictors of MACE(P＜0.05).ROC analysis showed that the combination of these 3 indicators achieved an area under the curve(AUC)of 0.948(95％CI:0.888-0.982),significantly higher than that of PAPi(AUC=0.863,95％CI:0.784-0.922),total myocardial ischemia burden(AUC=0.914,95％CI:0.844-0.959),CSI score(AUC=0.760,95％CI:0.668-0.837)when used alone(all P＜0.05).The combined test demonstrated a sensitivity of 84.37％and specificity of 96.05％.Conclusions PAPi,total myocardial ischemia burden and CSI score represent risk factors for MACE in elderly HFrEF patients.Their combined assessment provides high clinical value for predicting prognosis in this population.关键词
肺动脉搏动指数/心肌微循环/心力衰竭/老年/主要不良心血管事件Key words
pulmonary artery pulsatility index/myocardial microcirculation/heart failure/elderly/major adverse cardiovascular events分类
医药卫生引用本文复制引用
王国秋,葛立永,曾安宁,杨钦宇,李伟..肺动脉搏动指数联合心肌微循环指标对老年慢性射血分数降低心力衰竭患者主要不良心血管事件的预测价值[J].实用医学杂志,2026,42(8):1341-1346,6.基金项目
贵州省卫生健康委科学技术基金项目(编号:gzwkj2023-308) （编号:gzwkj2023-308）
