实用医学杂志2026，Vol.42Issue(9)：1525-1535,11.DOI:10.3969/j.issn.1006-5725.2026.09.006
色氨酸代谢重编程驱动肿瘤免疫逃逸的机制及中药增敏免疫治疗的研究进展
Research advances in mechanisms of tryptophan metabolic reprogramming-driven tumor immune escape and immune sensitization therapy of traditional chinese medicine
摘要
Abstract
As a crucial hub that links immune dysregulation and tumor progression,tryptophan metabo-lism has emerged as a transdisciplinary frontier in cancer research.This review initially delineates the functional heterogeneity of tryptophan-catabolizing enzymes and their molecular pathways that govern immune cell dynamics in the tumor microenvironment(TME)through dual mechanisms:tryptophan depletion and kynurenine(KYN)ac-cumulation.Subsequently,by concentrating on the metabolic characteristics of breast cancer,colorectal cancer,glioma,and epithelial ovarian cancer,we systematically analyze the histotype-specific reprogramming of trypto-phan metabolism.Finally,we assess the regulatory effects of traditional Chinese medicine(TCM)active ingredi-ents(monomers and compound formulas)on reshaping the TME by targeting tryptophan metabolic pathways.This review aims to offer mechanistic and translational insights for surmounting tumor metabolic adaptation barriers and enhancing immunotherapy efficacy.关键词
色氨酸代谢重编程/犬尿氨酸通路/吲哚胺-2,3-双加氧酶1/肿瘤免疫逃逸/程序性死亡配体1/中药增敏免疫治疗Key words
tryptophan metabolic reprogramming/kynurenine pathway/indoleamine 2,3-dioxygenase 1/tumor immune escape/programmed death-ligand 1/immune sensitization therapy of traditional Chinese medicine分类
医药卫生引用本文复制引用
张文洁,孙硕,任志悦,宫雨萌,孙有智,赵益..色氨酸代谢重编程驱动肿瘤免疫逃逸的机制及中药增敏免疫治疗的研究进展[J].实用医学杂志,2026,42(9):1525-1535,11.基金项目
国家自然科学基金项目(编号:82360961) （编号:82360961）
江西省自然科学基金项目(编号:20242BAB25562) （编号:20242BAB25562）
